Abstract
Impairments in memory functions are among the most robust correlates of schizophrenia and of poor functional outcomes in individuals with psychotic disorders. Prospective, longitudinal studies are crucial to determining the meaning of these deficits in relation to mechanisms associated with the onset and course of these disorders.
The objective of this review is to examine the literature concerning premorbid memory impairments during the prodromal phase of psychosis to address three primary questions 1) are memory impairments present among individuals with a clinical high risk syndrome? 2) are memory deficits in clinical high risk cases predictive of future conversion to psychosis? and 3) what are the underlying neural correlates of memory impairment in clinical high risk individuals and are they also predictive of future conversion?
PubMed and Google Scholar databases were systematically searched. The primary inclusion criteria were to select studies that 1) were original research articles published in a peer-reviewed journal in the past 25 years, 2) studied subjects at clinical high risk for psychosis or in the prodromal phase of illness, and 3) included examinations into verbal memory performance in those at clinical high risk for psychosis.
64 articles were identified and screened for eligibility. The review included 34 studies investigating verbal memory impairment in clinical high risk individuals compared to controls. The average effect size of verbal learning total recall was .58, indicating a moderate level of impairment in verbal learning among individuals at clinical high risk for psychosis as compared to healthy controls. Of studies that predicted time to conversion, indices of memory, particularly declarative and verbal working memory, were especially predictive of future conversion. Finally, when examining investigations of the neural correlates of memory dysfunction in the clinical high risk state, findings suggest altered activation and functional connectivity among medial temporal lobe regions may underlie differences in memory performance between clinical high risk individuals and healthy controls.
Findings to date strongly indicate that memory impairments are present during the premorbid phase of psychosis and that verbal memory impairment in particular is predictive of future conversion to psychosis. Evidence from fMRI studies is fairly consistent in showing greater activation of memory-related regions during retrieval among clinical high risk cases who convert, with less consistent evidence of altered functional connectivity in the encoding phase. These findings support the use of verbal learning and memory measures in the psychosis prediction and prevention field.
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References
Achim, A. M., & Lepage, M. (2005). Episodic memory-related activation in schizophrenia: meta-analysis. The British Journal of Psychiatry, 187(6), 500–509. https://doi.org/10.1192/bjp.187.6.500
Addington, J., Cornblatt, B. A., Cadenhead, K. S., Cannon, T. D., McGlashan, T. H., Perkins, D. O., et al. (2011). At clinical high risk for psychosis: outcome for nonconverters. American Journal of Psychiatry, 168(8), 800–805. https://doi.org/10.1176/appi.ajp.2011.10081191
Aleman, A., Hijman, R., De Haan, E. H., & Kahn, R. S. (1999). Memory impairment in schizophrenia: a meta-analysis. American Journal of Psychiatry, 156(9), 1358–1366. https://doi.org/10.1176/ajp.156.9.1358
Allen, P., Chaddock, C. A., Howes, O. D., Egerton, A., Seal, M. L., Fusar-Poli, P., et al. (2012). Abnormal relationship between medial temporal lobe and subcortical dopamine function in people with an ultra high risk for psychosis. Schizophrenia Bulletin, 38(5), 1040–1049. https://doi.org/10.1093/schbul/sbr017
Allen, P., Seal, M. L., Valli, I., Fusar-Poli, P., Perlini, C., Day, F., et al. (2011). Altered prefrontal and hippocampal function during verbal encoding and recognition in people with prodromal symptoms of psychosis. Schizophrenia Bulletin, 37(4), 746–756. https://doi.org/10.1093/schbul/sbp113
Andreasen, N. C., Paradiso, S., & O’Leary, D. S. (1998). “Cognitive dysmetria” as an integrative theory of schizophrenia: a dysfunction in cortical-subcortical-cerebellar circuitry? Schizophrenia Bulletin, 24(2), 203–218. https://doi.org/10.1093/oxfordjournals.schbul.a033321
Antoniades, M., Schoeler, T., Radua, J., Valli, I., Allen, P., Kempton, M. J., & McGuire, P. (2018). Verbal learning and hippocampal dysfunction in schizophrenia: A meta-analysis. Neuroscience and Biobehavioral Reviews, 86, 166–175. https://doi.org/10.1016/j.neubiorev.2017.12.001
Averbach, E., & Coriell, A. S. (1961). Short‐term memory in vision. Bell System Technical Journal, 40(1), 309–328. https://doi.org/10.1002/j.1538-7305.1961.tb03987.x
Baddeley, A. (1992). Working memory. Science, 255(5044), 556–559. https://doi.org/10.1126/science.1736359
Bang, M., Kim, K. R., Song, Y. Y., Baek, S., Lee, E., & An, S. K. (2015). Neurocognitive impairments in individuals at ultra-high risk for psychosis: who will really convert? Australian and New Zealand Journal of Psychiatry, 49(5), 462–470. https://doi.org/10.1177/2F0004867414561527
Barbato, M., Colijn, M. A., Keefe, R. S., Perkins, D. O., Woods, S. W., Hawkins, K. A., et al. (2013). The course of cognitive functioning over six months in individuals at clinical high risk for psychosis. Psychiatry Research, 206(2–3), 195–199. https://doi.org/10.1016/j.psychres.2012.10.013
Becker, H. E., Nieman, D. H., Wiltink, S., Dingemans, P. M., Van de Fliert, J. R., Velthorst, E., et al. (2010). Neurocognitive functioning before and after the first psychotic episode: does psychosis result in cognitive deterioration? Psychological Medicine, 40(10), 1599. https://doi.org/10.1017/s0033291710000048
Benedict, R. H. (1997). Brief visuospatial memory test-revised. PAR.
Benton, A. L. (1967). Problems of test construction in the field of aphasia. Cortex: A Journal Devoted to the Study of the Nervous System and Behavior, 3(1), 32–58. https://doi.org/10.1016/S0010-9452(67)80005-4
Bliss, T. V., & Collingridge, G. L. (1993). A synaptic model of memory: long-term potentiation in the hippocampus. Nature, 361(6407), 31. https://doi.org/10.1038/361031a0
Bodatsch, M., Brockhaus-Dumke, A., Klosterkötter, J., & Ruhrmann, S. (2015). Forecasting psychosis by event-related potentials—systematic review and specific meta-analysis. Biological Psychiatry, 77(11), 951–958. https://doi.org/10.1016/j.biopsych.2014.09.025
Bodatsch, M., Ruhrmann, S., Wagner, M., Müller, R., Schultze-Lutter, F., Frommann, I., et al. (2011). Prediction of psychosis by mismatch negativity. Biological Psychiatry, 69(10), 959–966. https://doi.org/10.1016/j.biopsych.2010.09.057
Bowie, C. R., & Harvey, P. D. (2006). Cognitive deficits and functional outcome in schizophrenia. Neuropsychiatric Disease and Treatment, 2(4), 531. https://doi.org/10.2147/2Fnedt.2006.2.4.531
Brandt, J. (1991). The Hopkins Verbal Learning Test: Development of a new memory test with six equivalent forms. The Clinical Neuropsychologist, 5(2), 125–142. https://doi.org/10.1080/13854049108403297
Brébion, G., Amador, X., David, A., Malaspina, D., Sharif, Z., & Gorman, J. M. (2000). Positive symptomatology and source-monitoring failure in schizophrenia—an analysis of symptom-specific effects. Psychiatry Research, 95(2), 119–131. https://doi.org/10.1016/s0165-1781(00)00174-8
Brewer, W. J., Francey, S. M., Wood, S. J., Jackson, H. J., Pantelis, C., Phillips, L. J., et al. (2005). Memory impairments identified in people at ultra-high risk for psychosis who later develop first-episode psychosis. American Journal of Psychiatry, 162(1), 71–78. https://doi.org/10.1176/appi.ajp.162.1.71
Cabeza, R., Dolcos, F., Graham, R., & Nyberg, L. (2002). Similarities and differences in the neural correlates of episodic memory retrieval and working memory. Neuroimage, 16(2), 317–330. https://doi.org/10.1006/nimg.2002.1063
Cannon, T. D. (2015). How schizophrenia develops: cognitive and brain mechanisms underlying onset of psychosis. Trends in Cognitive Sciences, 19(12), 744–756. https://doi.org/10.1016/2Fj.tics.2015.09.009
Cannon, T. D., Yu, C., Addington, J., Bearden, C. E., Cadenhead, K. S., Cornblatt, B. A., et al. (2016). An individualized risk calculator for research in prodromal psychosis. American Journal of Psychiatry, 173(10), 980–988. https://doi.org/10.1176/appi.ajp.2016.15070890
Cao, H., McEwen, S. C., Chung, Y., Chén, O. Y., Bearden, C. E., Addington, J., et al. (2019). Altered brain activation during memory retrieval precedes and predicts conversion to psychosis in individuals at clinical high risk. Schizophrenia Bulletin, 45(4), 924–933. https://doi.org/10.1093/schbul/sby122
Carrión, R. E., Cornblatt, B. A., McLaughlin, D., Chan, J., Auther, A. M., Olsen, R. H., & Javitt, D. C. (2015). Contributions of early cortical processing and reading ability to functional status in individuals at clinical high risk for psychosis. Schizophrenia Research, 164(1–3), 1–7. https://doi.org/10.1016/2Fj.schres.2015.01.030
Carrión, R. E., Goldberg, T. E., McLaughlin, D., Auther, A. M., Correll, C. U., & Cornblatt, B. A. (2011). Impact of neurocognition on social and role functioning in individuals at clinical high risk for psychosis. American Journal of Psychiatry, 168(8), 806–813. https://doi.org/10.1176/appi.ajp.2011.10081209
Carrión, R. E., McLaughlin, D., Auther, A. M., Olsen, R., Correll, C. U., & Cornblatt, B. A. (2015). The impact of psychosis on the course of cognition: a prospective, nested case-control study in individuals at clinical high-risk for psychosis. Psychological Medicine, 45(15), 3341–3354. https://doi.org/10.1017/s0033291715001233
Carrión, R. E., Walder, D. J., Auther, A. M., McLaughlin, D., Zyla, H. O., Adelsheim, S., & Niendam, T. (2018). From the psychosis prodrome to the first-episode of psychosis: No evidence of a cognitive decline. Journal of Psychiatric Research, 96, 231–238. https://doi.org/10.1016/j.jpsychires.2017.10.014
Chung, Y. S., Kang, D. H., Shin, N. Y., Yoo, S. Y., & Kwon, J. S. (2008). Deficit of theory of mind in individuals at ultra-high-risk for schizophrenia. Schizophrenia Research, 99(1–3), 111–118. https://doi.org/10.1016/j.schres.2007.11.012
Cohen, M. J. (1997). Children memory scale (CMS). The Psychological Corporation.
Coltheart, M. (1980). Iconic memory and visible persistence. Perception and Psychophysics, 27(3), 183–228. https://doi.org/10.3758/BF03204258
Corbetta, M., & Shulman, G. L. (2002). Control of goal-directed and stimulus-driven attention in the brain. Nature Reviews Neuroscience, 3(3), 201. https://doi.org/10.1038/nrn755
Cornblatt, B. A., Carrión, R. E., Auther, A., McLaughlin, D., Olsen, R. H., John, M., & Correll, C. U. (2015). Psychosis prevention: a modified clinical high risk perspective from the recognition and prevention (RAP) program. American Journal of Psychiatry, 172(10), 986–994. https://doi.org/10.1176/appi.ajp.2015.13121686
Cowan, N. (1988). Evolving conceptions of memory storage, selective attention, and their mutual constraints within the human information‐processing system. Psychological Bulletin, 104(2), 163. https://doi.org/10.1037/0033‐2909.104.2.163
Delis, D. C., Kramer, J. H., Kaplan, E., & Thompkins, B. A. O. (1987). CVLT: California verbal learning test-adult version: Manual. Psychological Corporation.
Eastvold, A. D., Heaton, R. K., & Cadenhead, K. S. (2007). Neurocognitive deficits in the (putative) prodrome and first episode of psychosis. Schizophrenia Research, 93(1–3), 266–277. https://doi.org/10.1016/j.schres.2007.03.013
Eisenacher, S., Rausch, F., Ainser, F., Englisch, S., Becker, A., Mier, D., et al. (2018). Early cognitive basic symptoms are accompanied by neurocognitive impairment in patients with an ‘at-risk mental state’for psychosis. Early Intervention in Psychiatry, 12(4), 586–595. https://doi.org/10.1111/eip.12350
Erickson, M. A., Ruffle, A., & Gold, J. M. (2016). A meta-analysis of mismatch negativity in schizophrenia: from clinical risk to disease specificity and progression. Biological Psychiatry, 79(12), 980–987. https://doi.org/10.1016/2Fj.biopsych.2015.08.025
Fougnie, D. (2008). The relationship between attention and working memory. In Johansen, N. B., New research on short-term memory (pp.1–45). Nova Science.
Frommann, I., Pukrop, R., Brinkmeyer, J., Bechdolf, A., Ruhrmann, S., Berning, J., & Gaebel, W. (2011). Neuropsychological profiles in different at-risk states of psychosis: executive control impairment in the early—and additional memory dysfunction in the late—prodromal state. Schizophrenia Bulletin, 37(4), 861–873. https://doi.org/10.1093/schbul/sbp155
Fusar-Poli, P., Borgwardt, S., Bechdolf, A., Addington, J., Riecher-Rössler, A., Schultze-Lutter, F., et al. (2013). The psychosis high-risk state: a comprehensive state-of-the-art review. JAMA Psychiatry, 70(1), 107–120. https://doi.org/10.1001/jamapsychiatry.2013.269
Gawęda, Ł, Moritz, S., & Kokoszka, A. (2012). Impaired discrimination between imagined and performed actions in schizophrenia. Psychiatry Research, 195(1), 1–8. https://doi.org/10.1016/j.psychres.2011.07.035
González-Ortega, I., & de los Mozos, V., Echeburúa, E., Mezo, M., Besga, A., de Azúa, S. R., González-Pinto, A., Gutierrez, M., Zorrilla, I., & González-Pinto, A. (2013). Working memory as a predictor of negative symptoms and functional outcome in first episode psychosis. Psychiatry Research, 206(1), 8–16. https://doi.org/10.1016/j.psychres.2012.08.025
Green, M. F. (1996). What are the functional consequences of neurocognitive deficits in schizophrenia? The American Journal of Psychiatry, 153(3), 321. https://doi.org/10.1176/ajp.153.3.321
Green, M. F., Marshall, B. D., Jr., Wirshing, W. C., Ames, D., Marder, S. R., McGurk, S., & Mintz, J. (1997). Does risperidone improve verbal working memory in treatment-resistant schizophrenia? American Journal of Psychiatry, 154(6), 799–804. https://doi.org/10.1176/ajp.154.6.799
Gross, G. (1987). Bonner skala für die beurteilung von basissymptomen: Manual, kommentar, dokumentationsbogen: BSABS. Springer.
Hall, R. C. (1995). Global assessment of functioning: a modified scale. Psychosomatics, 36(3), 267–275. https://doi.org/10.1016/s0033-3182(95)71666-8
Hambrecht, M., Lammertink, M., KlosterkÖtter, J., Matuschek, E., & Pukrop, R. (2002). Subjective and objective neuropsychological abnormalities in a psychosis prodrome clinic. The British Journal of Psychiatry, 181(S43), s30–s37. https://doi.org/10.1192/bjp.181.43.s30
Haut, K. M., van Erp, T. G., Knowlton, B., Bearden, C. E., Subotnik, K., Ventura, J., & Cannon, T. D. (2015). Contributions of feature binding during encoding and functional connectivity of the medial temporal lobe structures to episodic memory deficits across the prodromal and first-episode phases of schizophrenia. Clinical Psychological Science, 3(2), 159–174. https://doi.org/10.1177/2F2167702614533949
Hawkins, K. A., Addington, J., Keefe, R. S. E., Christensen, B., Perkins, D. O., Zipurksy, R., & McGlashan, T. H. (2004). Neuropsychological status of subjects at high risk for a first episode of psychosis. Schizophrenia Research, 67(2–3), 115–122. https://doi.org/10.1016/j.schres.2003.08.007
Hawkins, K. A., Keefe, R. S., Christensen, B. K., Addington, J., Woods, S. W., Callahan, J., et al. (2008). Neuropsychological course in the prodrome and first episode of psychosis: findings from the PRIME North America Double Blind Treatment Study. Schizophrenia Research, 105(1–3), 1–9. https://doi.org/10.1016/j.schres.2008.07.008
He, Y., Li, Z., Ma, X., Yuan, L., Ouyang, L., Tang, J., et al. (2019). Olfactory and cognitive functions in Chinese individuals at clinical high risk for psychosis. Psychiatry Research, 272, 51–53. https://doi.org/10.1016/j.psychres.2018.12.074
Henquet, C., Krabbendam, L., Dautzenberg, J., Jolles, J., & Merckelbach, H. (2005). Confusing thoughts and speech: source monitoring and psychosis. Psychiatry Research, 133(1), 57–63. https://doi.org/10.1016/j.psychres.2004.08.009
Higuchi, Y., Sumiyoshi, T., Seo, T., Miyanishi, T., Kawasaki, Y., & Suzuki, M. (2013). Mismatch negativity and cognitive performance for the prediction of psychosis in subjects with at-risk mental state. PLoS One, 8(1), e54080. https://doi.org/10.1371/journal.pone.0054080
Hou, C. L., Xiang, Y. T., Wang, Z. L., Everall, I., Tang, Y., Yang, C., et al. (2016). Cognitive functioning in individuals at ultra-high risk for psychosis, first-degree relatives of patients with psychosis and patients with first-episode schizophrenia. Schizophrenia Research, 174(1–3), 71–76. https://doi.org/10.1016/j.schres.2016.04.034
Hsieh, M. H., Shan, J. C., Huang, W. L., Cheng, W. C., Chiu, M. J., Jaw, F. S., et al. (2012). Auditory event-related potential of subjects with suspected pre-psychotic state and first-episode psychosis. Schizophrenia Research, 140(1–3), 243–249. https://doi.org/10.1016/j.schres.2012.06.021
Ittig, S., Studerus, E., Papmeyer, M., Uttinger, M., Koranyi, S., Ramyead, A., & Riecher-Rössler, A. (2015). Sex differences in cognitive functioning in at-risk mental state for psychosis, first episode psychosis and healthy control subjects. European Psychiatry, 30(2), 242–250. https://doi.org/10.1016/j.eurpsy.2014.11.006
Jahshan, C., Heaton, R. K., Golshan, S., & Cadenhead, K. S. (2010). Course of neurocognitive deficits in the prodrome and first episode of schizophrenia. Neuropsychology, 24(1), 109.
Javitt, D. C. (2000). Intracortical mechanisms of mismatch negativity dysfunction in schizophrenia. Audiology and Neurotology, 5(3–4), 207–215. https://doi.org/10.1159/000013882
Javitt, D. C., Steinschneider, M., Schroeder, C. E., & Arezzo, J. C. (1996). Role of cortical N-methyl-D-aspartate receptors in auditory sensory memory and mismatch negativity generation: implications for schizophrenia. Proceedings of the National Academy of Sciences, 93(21), 11962–11967. https://doi.org/10.1073/2Fpnas.93.21.11962
Johnsen, G. E., & Asbjørnsen, A. E. (2008). Consistent impaired verbal memory in PTSD: a meta-analysis. Journal of Affective Disorders, 111(1), 74–82. https://doi.org/10.1016/j.jad.2008.02.007
Johnson, M. K., & Raye, C. L. (2000). Cognitive and brain mechanisms of false memories and beliefs. Memory, Brain, and Belief, 35–86. Harvard University Press.
Kambeitz-Ilankovic, L., Haas, S. S., Meisenzahl, E., Dwyer, D. B., Weiske, J., Peters, H., et al. (2019). Neurocognitive and neuroanatomical maturation in the clinical high-risk states for psychosis: a pattern recognition study. NeuroImage: Clinical, 21, 101624. https://doi.org/10.1016/j.nicl.2018.101624
Karlsgodt, K. H., Glahn, D. C., van Erp, T. G., Therman, S., Huttunen, M., Manninen, M., & Cannon, T. D. (2007). The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects. Schizophrenia Research, 89(1–3), 191–197. https://doi.org/10.1016/j.schres.2006.08.016
Kayser, J., Tenke, C. E., Kroppmann, C. J., Alschuler, D. M., Fekri, S., Ben-David, S., & Bruder, G. E. (2014). Auditory event-related potentials and alpha oscillations in the psychosis prodrome: neuronal generator patterns during a novelty oddball task. International Journal of Psychophysiology, 91(2), 104–120. https://doi.org/10.1016/j.ijpsycho.2013.12.003
Keefe, R. S., Arnold, M. C., Bayen, U. J., & Harvey, P. D. (1999). Source monitoring deficits in patients with schizophrenia; a multinomial modelling analysis. Psychological Medicine, 29(4), 903–914. https://doi.org/10.1017/S0033291799008673
Keefe, R. S., Arnold, M. C., Bayen, U. J., McEvoy, J. P., & Wilson, W. H. (2002). Source-monitoring deficits for self-generated stimuli in schizophrenia: multinomial modeling of data from three sources. Schizophrenia Research, 57(1), 51–67. https://doi.org/10.1016/S0920-9964(01)00306-1
Keefe, R. S., Perkins, D. O., Gu, H., Zipursky, R. B., Christensen, B. K., & Lieberman, J. A. (2006). A longitudinal study of neurocognitive function in individuals at-risk for psychosis. Schizophrenia Research, 88(1–3), 26–35. https://doi.org/10.1016/j.schres.2006.06.041
Kelley, W. M., Miezin, F. M., McDermott, K. B., Buckner, R. L., Raichle, M. E., Cohen, N. J., et al. (1998). Hemispheric specialization in human dorsal frontal cortex and medial temporal lobe for verbal and nonverbal memory encoding. Neuron, 20(5), 927–936. https://doi.org/10.1016/S0896-6273(00)80474-2
Kim, J. S., Kornhuber, H. H., Schmid-Burgk, W., & Holzmüller, B. (1980). Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neuroscience Letters, 20(3), 379–382. https://doi.org/10.1016/0304-3940(80)90178-0
Kim, H. S., Shin, N. Y., Jang, J. H., Kim, E., Shim, G., Park, H. Y., et al. (2011). Social cognition and neurocognition as predictors of conversion to psychosis in individuals at ultra-high risk. Schizophrenia research, 130(1–3), 170–175. https://doi.org/10.1016/j.schres.2011.04.023
Koutsouleris, N., Davatzikos, C., Bottlender, R., Patschurek-Kliche, K., Scheuerecker, J., Decker, P., et al. (2012). Early recognition and disease prediction in the at-risk mental states for psychosis using neurocognitive pattern classification. Schizophrenia Bulletin, 38(6), 1200–1215. https://doi.org/10.1093/schbul/sbr037
Lappe, C., Trainor, L. J., Herholz, S. C., & Pantev, C. (2011). Cortical plasticity induced by short-term multimodal musical rhythm training. PLoS One, 6(6), e21493. https://doi.org/10.1371/journal.pone.0021493
Li, R. R., Lyu, H. L., Liu, F., Lian, N., Wu, R. R., Zhao, J. P., & Guo, W. B. (2018). Altered functional connectivity strength and its correlations with cognitive function in subjects with ultra-high risk for psychosis at rest. CNS Neuroscience and Therapeutics, 24(12), 1140–1148. https://doi.org/10.1111/cns.12865
Lin, A., Wood, S. J., Nelson, B., Brewer, W. J., Spiliotacopoulos, D., Bruxner, A., & Yung, A. R. (2011). Neurocognitive predictors of functional outcome two to 13 years after identification as ultra-high risk for psychosis. Schizophrenia Research, 132(1), 1–7. https://doi.org/10.1016/j.schres.2011.06.014
Lee, J., & Park, S. (2005). Working memory impairments in schizophrenia: a meta-analysis. Journal of Abnormal Psychology, 114(4), 599. https://doi.org/10.1037/0021-843X.114.4.599
Lee, T. Y., Shin, Y. S., Shin, N. Y., Kim, S. N., Jang, J. H., Kang, D. H., & Kwon, J. S. (2014). Neurocognitive function as a possible marker for remission from clinical high risk for psychosis. Schizophrenia Research, 153(1–3), 48–53. https://doi.org/10.1016/j.schres.2014.01.018
Lencz, T., Smith, C. W., McLaughlin, D., Auther, A., Nakayama, E., Hovey, L., & Cornblatt, B. A. (2006). Generalized and specific neurocognitive deficits in prodromal schizophrenia. Biological Psychiatry, 59(9), 863–871. https://doi.org/10.1016/j.biopsych.2005.09.005
Lindgren, M., Manninen, M., Laajasalo, T., Mustonen, U., Kalska, H., Suvisaari, J., et al. (2010). The relationship between psychotic-like symptoms and neurocognitive performance in a general adolescent psychiatric sample. Schizophrenia Research, 123(1), 77–85. https://doi.org/10.1016/j.schres.2010.07.025
Magnusson, K. (2020). Interpreting Cohen's d effect size: An interactive visualization (Version 2.1.1) [Web App]. R Psychologist. https://rpsychologist.com/d3/cohend/
McDonald, M., Christoforidou, E., Van Rijsbergen, N., Gajwani, R., Gross, J., Gumley, A. I., et al. (2019). Using online screening in the general population to detect participants at clinical high-risk for psychosis. Schizophrenia Bulletin, 45(3), 600–609. https://doi.org/10.1093/schbul/sby069
McGlashan, T., Walsh, B., and Woods, S. (2010). The psychosis-risk syndrome: Handbook for diagnosis and follow-up. Oxford University Press.
Moghaddam, B., & Javitt, D. (2012). From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment. Neuropsychopharmacology, 37(1), 4. https://doi.org/10.1038/npp.2011.181
Mori, K., Nagao, M., Yamashita, H., Morinobu, S., & Yamawaki, S. (2004). Effect of switching to atypical antipsychotics on memory in patients with chronic schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 28(4), 659–665. https://doi.org/10.1016/j.pnpbp.2004.01.019
Näätänen, R. (2008). Mismatch negativity (MMN) as an index of central auditory system plasticity. International Journal of Audiology, 47(sup2), S16–S20. https://doi.org/10.1080/14992020802340116
Nagai, T., Tada, M., Kirihara, K., Araki, T., Jinde, S., & Kasai, K. (2013). Mismatch negativity as a “translatable” brain marker toward early intervention for psychosis: a review. Frontiers in Psychiatry, 4, 115. https://doi.org/10.3389/fpsyt.2013.00115
Niendam, T. A., Bearden, C. E., Johnson, J. K., McKinley, M., Loewy, R., O’Brien, M., & Cannon, T. D. (2006). Neurocognitive performance and functional disability in the psychosis prodrome. Schizophrenia Research, 84(1), 100–111. https://doi.org/10.1016/j.schres.2006.02.005
Niendam, T. A., Bearden, C. E., Zinberg, J., Johnson, J. K., O’Brien, M., & Cannon, T. D. (2007). The course of neurocognition and social functioning in individuals at ultra high risk for psychosis. Schizophrenia Bulletin, 33(3), 772–781. https://doi.org/10.1093/schbul/sbm020
Ohmuro, N., Matsumoto, K., Katsura, M., Obara, C., Kikuchi, T., Hamaie, Y., et al. (2015). The association between cognitive deficits and depressive symptoms in at-risk mental state: a comparison with first-episode psychosis. Schizophrenia Research, 162(1–3), 67–73. https://doi.org/10.1016/j.schres.2015.01.008
PA, O. (1944). Filetest de copie d’une figure complex: Contribution a l’etude de la perception et de la memoire [Test of copying a complex figure; contribution to the study of perception and memory]. Archives de Psychologie, 30, 286–356.
Özgürdal, S., Littmann, E., Hauser, M., von Reventlow, H., Gudlowski, Y., Witthaus, H., et al. (2009). Neurocognitive performances in participants of at-risk mental state for schizophrenia and in first-episode patients. Journal of Clinical and Experimental Neuropsychology, 31(4), 392–401. https://doi.org/10.1080/13803390802206406
Perez, V. B., Woods, S. W., Roach, B. J., Ford, J. M., McGlashan, T. H., Srihari, V. H., & Mathalon, D. H. (2014). Automatic auditory processing deficits in schizophrenia and clinical high-risk patients: forecasting psychosis risk with mismatch negativity. Biological Psychiatry, 75(6), 459–469. https://doi.org/10.1016/j.biopsych.2013.07.038
Pflueger, M. O., Gschwandtner, U., Stieglitz, R. D., & Riecher-Rössler, A. (2007). Neuropsychological deficits in individuals with an at risk mental state for psychosis—working memory as a potential trait marker. Schizophrenia Research, 97(1–3), 14–24. https://doi.org/10.1016/j.schres.2007.09.003
Pukrop, R., Ruhrmann, S., Schultze-Lutter, F., Bechdolf, A., Brockhaus-Dumke, A., & Klosterkötter, J. (2007). Neurocognitive indicators for a conversion to psychosis: comparison of patients in a potentially initial prodromal state who did or did not convert to a psychosis. Schizophrenia Research, 92(1–3), 116–125. https://doi.org/10.1016/j.schres.2007.01.020
Pukrop, R., Schultze-Lutter, F., Ruhrmann, S., Brockhaus-Dumke, A., Tendolkar, I., Bechdolf, A., et al. (2006). Neurocognitive functioning in subjects at risk for a first episode of psychosis compared with first-and multiple-episode schizophrenia. Journal of Clinical and Experimental Neuropsychology, 28(8), 1388–1407. https://doi.org/10.1080/13803390500434425
Ragland, J. D., Laird, A. R., Ranganath, C., Blumenfeld, R. S., Gonzales, S. M., & Glahn, D. C. (2009). Prefrontal activation deficits during episodic memory in schizophrenia. American Journal of Psychiatry, 166(8), 863–874. https://doi.org/10.1176/appi.ajp.2009.08091307
Rey, A. (1941). L'examen psychologique dans les cas d'encéphalopathie traumatique.(Les problems.). Archives de Psychologie.
Riecher-Rössler, A., Aston, J., Ventura, J., Merlo, M., Borgwardt, S., Gschwandtner, U., & Stieglitz, R. D. (2008). The Basel Screening Instrument for Psychosis (BSIP): development, structure, reliability and validity. Fortschritte der Neurologie-Psychiatrie, 76(4), 207. https://doi.org/10.1055/s-2008-1038155
Roediger, H. L., & McDermott, K. B. (1995). Creating false memories: Remembering words not presented in lists. Journal of experimental psychology: Learning, Memory, and Cognition, 21(4), 803. https://psycnet.apa.org/doi/10.1037/0278-7393.21.4.803
Reilly, J. L., Harris, M. S., Khine, T. T., Keshavan, M. S., & Sweeney, J. A. (2007). Antipsychotic drugs exacerbate impairment on a working memory task in first-episode schizophrenia. Biological Psychiatry, 62(7), 818–821. https://doi.org/10.1016/j.biopsych.2006.10.031
Rey, A. (1941). L’examen psychologique dans les cas d’encéphalopathie traumatique. (Les problems.). Archives de Psychologie, 28, 215–285.
Sanada, K., de Azúa, S. R., Nakajima, S., Alberich, S., Ugarte, A., Zugasti, J., & González-Pinto, A. (2018). Correlates of neurocognitive functions in individuals at ultra-high risk for psychosis-A 6-month follow-up study. Psychiatry Research, 268, 1–7. https://doi.org/10.1016/j.psychres.2018.06.053
Schacter, D. L., Gilbert, D. T., & Wegner, D. M. (2009). Introducing psychology. Macmillan.
Schultze-Lutter, F., Addington, J., Ruhrmann, S., & Klosterkötter, J. (2007). Schizophrenia proneness instrument, adult version (SPI-A). Rome: Giovanni Fioriti. https://doi.org/10.1016/j.schres.2007.01.020
Seidman, L. J., Giuliano, A. J., Meyer, E. C., Addington, J., Cadenhead, K. S., Cannon, T. D., et al. (2010). Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis. Archives of General Psychiatry, 67(6), 578–588. https://doi.org/10.1001/archgenpsychiatry.2010.66
Seidman, L. J., Shapiro, D. I., Stone, W. S., Woodberry, K. A., Ronzio, A., Cornblatt, B. A., et al. (2016). Association of neurocognition with transition to psychosis: baseline functioning in the second phase of the North American prodrome longitudinal study. JAMA Psychiatry, 73(12), 1239–1248. https://doi.org/10.1001/jamapsychiatry.2016.2479
Shaikh, M., Valmaggia, L., Broome, M. R., Dutt, A., Lappin, J., Day, F., et al. (2012). Reduced mismatch negativity predates the onset of psychosis. Schizophrenia Research, 134(1), 42–48. https://doi.org/10.1016/j.schres.2011.09.022
Simon, A. E., Cattapan-Ludewig, K., Zmilacher, S., Arbach, D., Gruber, K., Dvorsky, D. N., et al. (2007). Cognitive functioning in the schizophrenia prodrome. Schizophrenia Bulletin, 33(3), 761–771. https://doi.org/10.1093/schbul/sbm018
Sitskoorn, M. M., Aleman, A., Ebisch, S. J., Appels, M. C., & Kahn, R. S. (2004). Cognitive deficits in relatives of patients with schizophrenia: a meta-analysis. Schizophrenia Research, 71(2–3), 285–295. https://doi.org/10.1016/j.schres.2004.03.007
Smith, E. E., & Jonides, J. (1998). Neuroimaging analyses of human working memory. Proceedings of the National Academy of Sciences, 95(20), 12061–12068. https://doi.org/10.1073/pnas.95.20.12061
Snitz, B. E., MacDonald III, A. W., & Carter, C. S. (2006). Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes. Schizophrenia Bulletin, 32(1), 179–194. https://academic.oup.com/schizophreniabulletin/article/32/1/179/2888585
Soyata, A. Z., Akışık, S., İnhanlı, D., Noyan, H., & Üçok, A. (2018). Relationship of obsessive-compulsive symptoms to clinical variables and cognitive functions in individuals at ultra high risk for psychosis. Psychiatry Research, 261, 332–337. https://doi.org/10.1016/j.psychres.2018.01.004
Squire, L. R. (1987). Memory and brain. New York, NY, US: Oxford University Press.
Stanford, A. D., Messinger, J., Malaspina, D., & Corcoran, C. M. (2011). Theory of Mind in patients at clinical high risk for psychosis. Schizophrenia Research, 131(1–3), 11–17. https://doi.org/10.1016/j.schres.2011.06.005
Stanislaw, H., & Todorov, N. (1999). Calculation of signal detection theory measures. Behavior Research Methods, Instruments, & Computers, 31(1), 137–149. https://doi.org/10.3758/BF03207704
Stallings, G., Boake, C., & Sherer, M. (1995). Comparison of the California verbal learning test and the Rey auditory verbal learning test in head-injured patients. Journal of Clinical and Experimental Neuropsychology, 17(5), 706–712. https://doi.org/10.1080/01688639508405160
Tatsumi, I. F., & Watanabe, M. (2009). Verbal memory. In Binder, M. D., Hirokawa, N., & Windhorst, U., Encyclopedia of neuroscience (pp. 4176–4178). Springer.
Tulving, E. (1972). Episodic and semantic memory. In E. Tulving and W. Donaldson, Organization of memory. Oxford, England: Academic Press.
Üçok, A., Direk, N., Koyuncu, A., Keskin-Ergen, Y., Yüksel, Ç., Güler, J., et al. (2013). Cognitive deficits in clinical and familial high risk groups for psychosis are common as in first episode schizophrenia. Schizophrenia Research, 151(1–3), 265–269. https://doi.org/10.1016/j.schres.2013.10.030
Valli, I., Stone, J., Mechelli, A., Bhattacharyya, S., Raffin, M., Allen, P., et al. (2011). Altered medial temporal activation related to local glutamate levels in subjects with prodromal signs of psychosis. Biological Psychiatry, 69(1), 97–99. https://doi.org/10.1016/j.biopsych.2010.08.033
Valli, I., Tognin, S., Fusar-Poli, P., & Mechelli, A. (2012). Episodic memory dysfunction in individuals at high-risk of psychosis: a systematic review of neuropsychological and neurofunctional studies. Current Pharmaceutical Design, 18(4), 443–458. https://doi.org/10.2174/138161212799316271
van Erp, T. G., Lesh, T. A., Knowlton, B. J., Bearden, C. E., Hardt, M., Karlsgodt, K. H., & Nuechterlein, K. (2008). Remember and know judgments during recognition in chronic schizophrenia. Schizophrenia Research, 100(1–3), 181–190. https://doi.org/10.1016/j.schres.2007.09.021
Velthorst, E., Meyer, E. C., Giuliano, A. J., Addington, J., Cadenhead, K. S., Cannon, T. D., & Walker, E. F. (2019). Neurocognitive profiles in the prodrome to psychosis in NAPLS-1. Schizophrenia Research: Advance online publication. https://doi.org/10.1016/j.schres.2018.07.038
Wechsler, D. (1945). Wechsler memory scale. The Psychological Corporation.
Wechsler, D. (1991). Wechsler intelligence scale for children–3rd edition manual. The Psychological Corporation.
Wechsler, D. (1997). WAIS-III administration and scoring manual. The Psychological Corporation.
Whyte, M. C., McIntosh, A. M., Johnstone, E. C., & Lawrie, S. M. (2005). Declarative memory in unaffected adult relatives of patients with schizophrenia: a systematic review and meta-analysis. Schizophrenia Research, 78(1), 13–26. https://doi.org/10.1016/j.schres.2005.05.018
Wood, S. J., Brewer, W. J., Koutsouradis, P., Phillips, L. J., Francey, S. M., Proffitt, T. M., et al. (2007). Cognitive decline following psychosis onset: data from the PACE clinic. The British Journal of Psychiatry, 191(S51), s52–s57. https://doi.org/10.1192/bjp.191.51.s52
Woodberry, K. A., Seidman, L. J., Giuliano, A. J., Verdi, M. B., Cook, W. L., & McFarlane, W. R. (2010). Neuropsychological profiles in individuals at clinical high risk for psychosis: relationship to psychosis and intelligence. Schizophrenia Research, 123(2–3), 188–198. https://doi.org/10.1016/j.schres.2010.06.021
Yung, A. R., Yuen, H. P., Mcgorry, P. D., Phillips, L. J., Kelly, D., Dell’Olio, M., et al. (2005). Mapping the onset of psychosis: the comprehensive assessment of at-risk mental states. Australian and New Zealand Journal of Psychiatry, 39(11–12), 964–971. https://doi.org/10.1080/2Fj.1440-1614.2005.01714.x
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This paper was supported by a National Science Foundation Graduate Research Fellowship Grant to Rashina Seabury (Grant #DGE1752134).
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Seabury, R.D., Cannon, T.D. Memory Impairments and Psychosis Prediction: A Scoping Review and Theoretical Overview. Neuropsychol Rev 30, 521–545 (2020). https://doi.org/10.1007/s11065-020-09464-2
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DOI: https://doi.org/10.1007/s11065-020-09464-2