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Unraveling neuroHIV in the Presence of Substance Use Disorders

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Abstract

This special issue contains 10 invited review papers that highlighted and extended the presentations at the NIDA-sponsored workshop “Unraveling NeuroAIDS in the Presence of Substance Use Disorders” at the 25th Society on NeuroImmune Pharmacology conference in 2019. The topics covered by these papers focused on the interactive, additive or synergistic effects of substance use disorders (SUD) with HIV infection on the immune system and on neuropathogenesis. These papers reviewed four categories of substances of abuse (opioids, tobacco, stimulants, and cannabis) and how comorbid HIV infection (including models with HIV proteins, HIV transgenic rodent models and SIV) might further impact the dysregulated dopaminergic and immune systems, and the subsequent neuropathogenesis and behavioral disorders known as HIV-associated neurological disorders (HAND). These reviews provided detailed background knowledge regarding how each of these addictive substances and HIV individually or collectively affected the immune system at the cellular, molecular and system levels, and the subsequent clinical and behavioral outcomes. The authors also identified gaps, confounds or constraints in the current disease models and approaches, and proposed future research directions.

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References

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Authors and Affiliations

  1. Division of Neuroscience and Behavior, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA

    Yu Lin & Roger Sorensen

  2. Department of Microbiology and Immunology, Chicago Medical School, and Center for Cancer Cell Biology, Immunology and Infection, Rosalind Franklin University, North Chicago, IL, USA

    Johnny J. He

  3. Department of Diagnostic Radiology and Nuclear Medicine, and Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA

    Linda Chang

  4. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Linda Chang

  5. Department of Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA

    Linda Chang

Authors
  1. Yu Lin
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  2. Johnny J. He
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  3. Roger Sorensen
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  4. Linda Chang
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Correspondence to Linda Chang.

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Lin, Y., He, J.J., Sorensen, R. et al. Unraveling neuroHIV in the Presence of Substance Use Disorders. J Neuroimmune Pharmacol 15, 578–583 (2020). https://doi.org/10.1007/s11481-020-09967-y

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  • DOI: https://doi.org/10.1007/s11481-020-09967-y

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