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Astragaloside IV inhibits cell proliferation and metastasis of breast cancer via promoting the long noncoding RNA TRHDE-AS1

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Abstract

Astragaloside IV (ASV), which has several pharmacological abilities, shows potential therapeutic effects on certain cancers by regulating the expression of long noncoding RNA (lncRNA). However, the anticancer role that ASV plays by regulating lncRNAs in breast cancer remains unknown. In this study, we first demonstrated that the lncRNA of TRHDE antisense RNA 1 (TRHDE-AS1) was downregulated in breast cancer tissues and cells. Low TRHDE-AS1 expression is associated with poor outcomes in patients with breast cancer and potentially contributes to the aggressive tumor biology of breast cancer. Furthermore, ASV significantly increased TRHDE-AS1 expression in a dose- and time-dependent manner in breast cancer cells. By upregulating TRHDE-AS1, ASV repressed breast cancer cell growth and metastasis both in vitro and in vivo. Taken together, our data indicated that TRHDE-AS1 participates in the anticancer role of ASV in breast cancer, which provides evidence for the application of ASV for breast cancer therapy.

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Acknowledgements

This work was supported by grants from Traditional Chinese Medical science and technology plan of Zhejiang Province (2020ZA086, 2020ZQ036).

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Authors and Affiliations

  1. Department of Breast Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, 261 Huansha Road, Hangzhou, 310006, China

    Shufang Hu

  2. School of Life Science, Huzhou University, 759 Erhuan East Road, Huzhou, 313000, Zhejiang, China

    Weihong Zheng

  3. Department of Traditional Chinese Medicine, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, 261 Huansha Road, Hangzhou, 310006, China

    Li Jin

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  1. Shufang Hu
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  2. Weihong Zheng
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Correspondence to Li Jin.

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Hu, S., Zheng, W. & Jin, L. Astragaloside IV inhibits cell proliferation and metastasis of breast cancer via promoting the long noncoding RNA TRHDE-AS1. J Nat Med 75, 156–166 (2021). https://doi.org/10.1007/s11418-020-01469-8

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  • DOI: https://doi.org/10.1007/s11418-020-01469-8

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