Skip to main content
SpringerLink
Log in

Investigating Physicochemical and Biological Properties of Chemical Silver Nanoparticles and Green Silver Nanoparticles Mediated with Morus alba L. Extracts and the Related Antimicrobial Mechanism

  • Original Paper
  • Published:
Journal of Cluster Science Aims and scope Submit manuscript

Abstract

In order to investigate the physicochemical properties and bioactivities of AgNPs prepared using green and chemical approaches and further explore the related antibacterial mechanism, one kind of chemical AgNPs (C-AgNPs) and three kinds of green AgNPs (G-AgNPs) mediated with aqueous extracts of Morus alba L. were prepared and characterized. All G-AgNPs displayed higher antioxidant activities in DPPH radical scavenging, reducing power and total antioxidant assays than C-AgNPs and extracts. Meanwhile, all G-AgNPs exerted significantly (P < 0.05) enhanced antimicrobial activities against various pathogens compared with C-AgNPs and extracts. Among prepared AgNPs, ML-AgNPs mediated with aqueous extract of Morus alba L. leaves exhibited the most powerful antibacterial effect with the largest inhibition zones (13.11 ± 0.76 mm for S. aureus, 13.27 ± 0.22 mm for E. coli) and the lowest minimum inhibition concentrations against S. aureus (6.125 μg/ml) and E. coli (3.125 μg/ml). ML-AgNPs could inhibit the growths of S. aureus and E. coli in time- and dose-dependent modes, and even could disrupt the bacterial structure integrality resulting in the leakage of intracellular contents. G-AgNPs, especially ML-AgNPs, with remarkable bioactivities could replace C-AgNPs as related agents applied in agriculture and medicine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. M.S. Akhtar, J. Panwar, and and Y.S. Yun (2013). Acs Sustainable Chemistry & Engineering 1, 591–602.

  2. A. Khatua, E. Priyadarshini, P. Rajamani, A. Patel, J. Kumar, A. Naik, M. Saravanan, H. Barabadi, A. Prasad, l. Ghosh, B. Paul, and R. Meena (2019). J. Cluster Sci. 31, (1), 125–131.

  3. E.Y. Ahn, and Y. Park (2020). Materials Science and Engineering C 116, 111253.

    CAS  PubMed  Google Scholar 

  4. A. Kalia, P. Manchanda, S. Bhardwaj, and G. Singh (2020). Inorganic and Nano-Metal Chemistry 50, 1053-1062.

    CAS  Google Scholar 

  5. M.A. Odeniyi, V.C. Okumah, B.C. Adebayo-Tayo, and O.A. Odeniyi (2020). Sustainable Chemistry and Pharmacy 15, 100197.

    Google Scholar 

  6. S.M. Sirry, S. Ali, A. Abdelaziz, and A. Mohamed (2020). Advances in Natural Sciences-Nanoscience and Nanotechnology 11 (3), 035017.

    CAS  Google Scholar 

  7. A.G. Al-Nuairi, K.A. Mosa, M.G. Mohammad, A. El-Keblawy, and H. Alawadhi (2019). Biol. Trace Elem. Res. 194, (2), 560-569.

    PubMed  Google Scholar 

  8. M. Khan, M.R. Shaik, S.F. Adil, S.T. Khan, A. Al-Warthan, M.R.H. Siddiqui, M.N. Tahir, and W. Tremel (2018). Dalton Trans. 47, 11988-12010.

    CAS  PubMed  Google Scholar 

  9. R. Rajan, K. Chandran, S.L. Harper, S.-I. Yun, and P.T. Kalaichelvan (2015). Ind. Crop. Prod. 70, 356-373.

    CAS  Google Scholar 

  10. M. Miljkovic, V. Lazic, S. Davidovic, A. Milivojevic, J. Papan, M.M. Fernandes, S. Lanceros-Mendez, S.P. Ahrenkiel, and J.M. Nedeljkovic 2020. J. Inorg. Organomet. Polym. Mater. 30, (7), 2598-2607.

    CAS  Google Scholar 

  11. S. Rajeshkumar, and L.V. Bharath (2017). Chem-Biol. Interact. 273, 219-227.

    CAS  PubMed  Google Scholar 

  12. R. Guimaraes, L. Barros, J.C.M. Barreira, M.J. Sousa, A.M. Carvalho, and I. Ferreira (2010). Food Chem. Toxicol. 48, (1), 99-106.

    CAS  PubMed  Google Scholar 

  13. T. Rajkumar, A. Sapi, G. Das, T. Debnath, A. Ansari, and J.K. Patra (2019). J. Photochem. Photobiol. B-Biol. 193, 1-7.

    CAS  Google Scholar 

  14. A.-R. Phull, Q. Abbas, A. Ali, H. Raza, S.J. Kim, M. Zia, and I.-u. Haq (2016). Future Journal of Pharmaceutical Sciences 2, (1), 31-36.

    Google Scholar 

  15. S. Kumar, R.K. Majhi, A. Singh, M. Mishra, A. Tiwari, S. Chawla, P. Guha, B. Satpati, H. Mohapatra, L. Goswami, and C. Goswami (2019). ACS Appl. Mater. Interfaces 11, (46), 42998-43017.

    CAS  PubMed  Google Scholar 

  16. S. Mickymaray (2019). Biomolecules, 9, (11), 662.

    CAS  PubMed Central  Google Scholar 

  17. R. Rani, D. Sharma, M. Chaturvedi, and J.P. Yadav (2020). Chem. Pap. 74, (6), 1817-1830.

    CAS  Google Scholar 

  18. S. Muthupandian, B. Ramachandran, and H. Barabadi (2018). Microbial Pathogenesis 114, 180-192.

    Google Scholar 

  19. S. Ahmed, M. Ahmad, B.L. Swami, and S. Ikram (2016). J Adv Res 7, 17-28.

    CAS  PubMed  Google Scholar 

  20. F.A. Alharbi, A.A. Alarfaj (2020). J. King Saud Univ. Sci. 32, 1346-1352.

    Google Scholar 

  21. S.S. Dash, S. Samanta, S. Dey, B. Giri, and S.K. Dash (2020). Biol. Trace Elem. Res. 198, 681–696.

    CAS  PubMed  Google Scholar 

  22. L.W. Chang, L.J. Juang, B.S. Wang, M.Y. Wang, H.M. Tai, W.J. Hung, Y.J. Chen, and M.H. Huang (2011). Food Chem. Toxicol. 49, (4), 785-790.

    CAS  PubMed  Google Scholar 

  23. A. Gryn-Rynko, G. Bazylak, and D. Olszewska-Slonina (2016). Biomedicine & Pharmacotherapy 84, 628-636.

    CAS  Google Scholar 

  24. P. Wen, T.G. Hu, R.J. Linhardt, S.T. Liao, H. Wu, and Y.X. Zou (2019). Trends Food Sci. Technol. 83, 138-158.

    CAS  Google Scholar 

  25. C. Wang, Z. Chen, L. Xu, and H. Chen (2020). FINE CHEMICALS (In Chinese). https://doi.org/10.13550/j.jxhg.20200540

  26. C. Wei, J. C. Zhao, B. Tao, J. H. Xie, W. K. Liang, and V. Gowd (2016). J. Funct. Foods 27, 472-482.

    Google Scholar 

  27. M.L. Cho, H.S. Lee, I.J. Kang, M.H. Won, and S.G. You (2011). Food Chem. 127, (3), 999-1006.

    CAS  PubMed  Google Scholar 

  28. E.Z. Gomaa (2017). Journal, genetic engineering & biotechnology 15, (1), 49–57.

  29. C. Dipankar, and S. Murugan (2012). Colloids Surf. B Biointerfaces 98, 112-119.

    CAS  PubMed  Google Scholar 

  30. K. J. Li, G. L. Guan, J. X. Zhu, H. Wu, and Q. J. Sun (2019). Food Control 96, 234-243.

    CAS  Google Scholar 

  31. G.d.S. Dannenberg, G.D. Funck, W.P. da Silva, and A.M. Fiorentini (2019). Food Control 95, 115–120.

  32. Y. Pan, L.-B. Zheng, Y. Mao, J. Wang, L.-S. Lin, Y.-Q. Su, and Y. Li (2019). Dev. Comp. Immunol. 92, 43-49.

    CAS  PubMed  Google Scholar 

  33. R. Parameshwaran, S. Kalaiselvam, and R. Jayavel (2013). Mater. Chem. Phys. 140, (1), 135-147.

    CAS  Google Scholar 

  34. U. Suriyakalaa, J.J. Antony, S. Suganya, D. Siva, R. Sukirtha, S. Kamalakkannan, P.B.T. Pichiah, and S. Achiraman (2013). Colloids Surf. B Biointerfaces 102, 189-194.

    CAS  PubMed  Google Scholar 

  35. A. Ahmad, F. Syed, A. Shah, Z. Khan, K. Tahir, A.U. Khan, and Q.P. Yuan (2015). Rsc Advances 5, (90), 73793-73806.

    CAS  Google Scholar 

  36. D. Sarvamangala, K. Kondala, N. Sivakumar, M.S. Babu, and S. Manga (2013). Int. Res. J. Pharm. 4, (3), 240-243.

    CAS  Google Scholar 

  37. A.K. Jha, K. Prasad, V. Kumar, and K. Prasad (2009). Biotechnol. Prog. 25, (5), 1476-1479.

    CAS  PubMed  Google Scholar 

  38. V. Chahar, B. Sharma, G. Shukla, A. Srivastava, and A. Bhatnagar (2018). Colloid Surf. A-Physicochem. Eng. Asp. 554, 149-155.

    CAS  Google Scholar 

  39. D. Cruz, P.L. Fale, A. Mourato, P.D. Vaz, M.L. Serralheiro, and A.R.L. Lino (2010). Colloids Surf. B Biointerfaces 81, (1), 67-73.

    CAS  PubMed  Google Scholar 

  40. P.B.E. Kedi, F.E. Meva, L. Kotsedi, E.L. Nguemfo, C.B. Zangueu, A.A. Ntoumba, H.E.A. Mohamed, A.B. Dongmo, and M. Maaza (2018). Int. J. Nanomedicine 13, 8537-8548.

    CAS  PubMed  PubMed Central  Google Scholar 

  41. S. Kummara, M.B. Patil, and T. Uriah (2016). Biomed. Pharmacother. 84, 10-21.

    CAS  PubMed  Google Scholar 

  42. K. Mortezaee, M. Najafi, H. Samadian, H. Barabadi, A. Ahmadi (2019). Chemico Biological Interactions, 312, 108814.

    CAS  PubMed  Google Scholar 

  43. N.S. Wigginton, A. De Titta, F. Piccapietra, J. Dobias, V.J. Nesatty, M.J.F. Suter, and R. Bernier-Latmani (2010). Environ. Sci. Technol. 44, (6), 2163-2168.

    CAS  PubMed  Google Scholar 

  44. J. Das, and P. Velusamy (2013). Mater. Res. Bull. 48, 4531-4537.

    CAS  Google Scholar 

  45. D. D. Sun, W. W. Zhang, Z. P. Mou, Y. Chen, F. Guo, E. D. Yang, and W. Y. Wang (2017). ACS Appl. Mater. Interfaces 9, (11), 10047–1 0060.

  46. M.A. Quinteros, C.A. Viviana, R. Onnainty, V.S. Mary, M.G. Theumer, G.E. Granero, M.G. Paraje, and P.L. Paez (2018). Int. J. Biochem. Cell Biol. 104, 87-93.

    CAS  PubMed  Google Scholar 

  47. R. Balachandar, P. Gurumoorthy, N. Karmegam, H. Barabadi, R. Subbaiya, K. Anand, P. Boomi, and M. Saravanan (2019). J. Cluster Sci. 30, (6), 1481-1488.

    CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by the grant from the Tianjin Municipal Science and Technology Foundation (Grant No. 18PTZWHZ00190) and National Natural Science Foundation of China (Grant No. 31371879).

Author information

Authors and Affiliations

  1. Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, People’s Republic of China

    Chunli Wang, Yanan Jia, Zhongqin Chen, Ruilin Li, Nannan Li, Qirou Wang & Haixia Chen

  2. Tianjin Agricultural University, Tianjin, 300384, People’s Republic of China

    Min Zhang

  3. State Key Laboratory of Nutrition and Safety, Tianjin University of Science & Technology, Tianjin, 300457, People’s Republic of China

    Min Zhang

Authors
  1. Chunli Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yanan Jia
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Zhongqin Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ruilin Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Nannan Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Qirou Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Min Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Haixia Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Haixia Chen.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 1692 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, C., Jia, Y., Chen, Z. et al. Investigating Physicochemical and Biological Properties of Chemical Silver Nanoparticles and Green Silver Nanoparticles Mediated with Morus alba L. Extracts and the Related Antimicrobial Mechanism. J Clust Sci 33, 61–71 (2022). https://doi.org/10.1007/s10876-020-01932-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10876-020-01932-2

Keywords

Search

Navigation