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Conjugation of 1-Aminoadamantanes and 5-Trifluoromethylhydantoins by 1,3-Dipolar Cycloaddition

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Abstract

A synthetic approach was proposed for combining pharmacophore scaffolds, namely, 1-aminoadamantanes and 5-trifluoromethylhydantoins by the copper-catalyzed 1,3-dipolar alkyne-azide cycloaddition reaction.

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Funding

This work was performed within the framework of the governmental task for 2019 (no. 0090-2019-0001).

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 142432, Moscow, Russia

    V. B. Sokolov, A. Yu. Aksinenko, T. V. Goreva, T. A. Epishina & V. I. Shestov

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  1. V. B. Sokolov
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  2. A. Yu. Aksinenko
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  3. T. V. Goreva
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  4. T. A. Epishina
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  5. V. I. Shestov
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Correspondence to A. Yu. Aksinenko.

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Sokolov, V.B., Aksinenko, A.Y., Goreva, T.V. et al. Conjugation of 1-Aminoadamantanes and 5-Trifluoromethylhydantoins by 1,3-Dipolar Cycloaddition. Russ J Gen Chem 90, 1831–1835 (2020). https://doi.org/10.1134/S1070363220100035

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  • DOI: https://doi.org/10.1134/S1070363220100035

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