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Preparation of Single Crystal of Inosine Induced by Sulfosalicylic Acid

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Abstract

For improving solubility of inosine, its β-form has been designed and prepared from inosine powder upon induction by sulfosalicylic acid. A single crystal of β-form inosine has been grown. The structure of β-form inosine has been characterized by XRPD, NMR and single-crystal X-ray crystallography. The crystal structure of β-form inosine demonstrates the layered structure based on a primary asymmetric cyclic hydrogen-bonded tetramer R44(14) based on the hetero-nitrogen and the hydroxyl group of inosine molecules. The single crystal exhibits the spiral structure along b axis formed due to O–H···O and O–H···N hydrogen bonds. As a result, water solubility under 37°C of inosine β-form is higher than that of inosine powder, and β-form inosine is hygroscopically more stable at 98% RH with respect to inosine powder. The β-form of inosine demonstrates the improved in vitro activity against liver cancer cells compared to inosine powder.

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Funding

This work was supported by Joint Guidance Project of Natural Science Foundation of Heilongjiang Province (grant no. LH2019H059).

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Authors and Affiliations

  1. College of Pharmacy, Jiamusi University, 154007, Jiamusi, China

    Y. N. Zhang, Y. L. Liu, L. X. Liu, Y. R. Feng, L. L. Wu, L. Zhang, Y. J. Zhang, D. Y. Zou, L. Chang, X. Su, G. D. Cheng & C. X. Wang

  2. The First Affiliated Hospital of Jiamusi University, Heilongjiang Province, 154007, Jiamusi, China

    X. S. Zhang

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Zhang, Y.N., Liu, Y.L., Liu, L.X. et al. Preparation of Single Crystal of Inosine Induced by Sulfosalicylic Acid. Russ J Gen Chem 90, 1968–1973 (2020). https://doi.org/10.1134/S1070363220100205

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