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Efficient Synthesis of Isoquinoline and Its Derivatives: From Metal Сatalysts to Catalyst-free Processes in Water

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Abstract

Isoquinolines constitute an important class of natural alkaloids, that demonstrate a wide range of biological activities. Therefore, development of new methods for efficient synthesis of isoquinoline and its derivatives has attracted considerable attention of chemists and pharmacologists over recent years. In this review the progress of isoquinoline synthesis that provides creative inspiration and expands novel ideas for researchers in this field is summarized.

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Funding

The generous financial support from the National Natural Science Foundation of China (nos. 51773057 and 21877034), Natural Science Foundation of Hunan Provincial (no. 2020JJ4028) and Hunan Provincial Education Department Scientific Research Fund (no. 18B221) are gratefully acknowledged.

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  1. School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, 411201, Hunan, Xiangtan, China

    Yajun Yu, Meng Guan, Yun-Hui Zhao, Wenlin Xie, Zhihua Zhou & Zilong Tang

  2. Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032, Shanghai, China

    Yun-Hui Zhao

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Yu, Y., Guan, M., Zhao, YH. et al. Efficient Synthesis of Isoquinoline and Its Derivatives: From Metal Сatalysts to Catalyst-free Processes in Water. Russ J Gen Chem 90, 2012–2027 (2020). https://doi.org/10.1134/S1070363220100266

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