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The calcination temperature effect in the synthesis of nanohydroxyapatite: characterization and its application as a nanocarrier

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Abstract

Drug delivery is the process of administering drugs at a specific amount in a specific site. Hydroxyapatite (HA) is reported as a drug carrier because of its unique properties such as high biodegradability, biocompatibility and drug-loading capacity, easy preparation, sterilization and cost-effective production. In the present study, the nanohydroxyapatite was synthesized at various calcination temperatures by the sol–gel route. The results revealed that the synthesized HA at 700 °C had the highest crystallinity. Moreover, the loading content of ampicillin was studied on HA samples synthesized at different calcination temperatures. It is considered that synthesized HA at 500 °C provided appropriate surface for ampicillin loading. The synthesized HA was characterized by scanning electron microscopy, X-ray diffraction, Fourier transform infrared and UV/Vis spectroscopy techniques before and after ampicillin loading.

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Correspondence to Sh. Hosseini or S. Khaksar.

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Fatemeh Mohammadi has received research grants from “Morvarid CASPIAN” company. All other authors report no conflict of interest relevant to this article.

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Mohammadi, F., Hosseini, S., Khaksar, S. et al. The calcination temperature effect in the synthesis of nanohydroxyapatite: characterization and its application as a nanocarrier. Appl Nanosci 13, 213–219 (2023). https://doi.org/10.1007/s13204-020-01603-8

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  • DOI: https://doi.org/10.1007/s13204-020-01603-8

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