Abstract
Post-transcriptional chemical modification of RNA is rapidly emerging as a key player in regulating gene expression and has propelled the development of ‘epitranscriptomics’ or ‘RNA epigenetics’ as a frontier area of research. Several RNA modifications are known to decorate RNAs and impact its structure and function. One such recently discovered modification is acetylation of RNA i.e. N4-acetylcytidine (ac4C) chemical modification. N4-acetylcytidine is an ancient and evolutionarily conserved modification, which maps to a wide spectrum of RNAs from archaea bacteria to humans. This modification results in a variety of functional outcomes which impact normal development and disease. In this review, we summarize the recent progress, emerging methods, biological implications and the future challenges for ac4C modification.
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Acknowledgements
P.K. acknowledges DST-SERB, Government of India for funding [Grant Number CRG/2018/000492 (to P.K.)]. Infrastructural and financial support from BITS Pilani-Hyderabad Campus, India is also acknowledged. K.R. acknowledges fellowship from BITS Pilani-Hyderabad Campus, India.
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This study was funded by an extramural grant from DST-SERB, Government of India [Grant Number CRG/2018/000492 (to P.K.)].
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Karthiya, R., Wasil, S.M. & Khandelia, P. Emerging role of N4-acetylcytidine modification of RNA in gene regulation and cellular functions. Mol Biol Rep 47, 9189–9199 (2020). https://doi.org/10.1007/s11033-020-05963-w
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DOI: https://doi.org/10.1007/s11033-020-05963-w