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A new insight into formation of 3D porous biomaterials

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Abstract

The degradation of poly(\(\varepsilon\)-caprolactone)/poly(l-lactic acid) (PCL/PLLA) electrospun membrane was carried out in the phosphate buffer of esterase and water, respectively. A three-dimensional (3D) porous morphology was cultivated during esterase degradation, which was confirmed by scanning electronic microscope (SEM), while the structural evolution was analyzed by differential scanning calorimetry (DSC) combining with wide-angle X-ray diffraction (WAXD). Compared with hydrolysis, the degradation rate of enzymolysis was significantly faster. With the rapid decline in PCL crystallinity, the crystallinity of PLLA increased slightly after enzymolysis. The formation of porous morphology should be attributed to the relatively rapid degradation of PCL crystal and PLLA amorphous region attacked by esterase. Also, the number of micropores on the fiber surface increased with degradation time, which provides new ideas for preparing porous materials with higher porosity.

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Acknowledgements

The authors would like to thank Dr. Xiangyang Li for assistance on the SR-\({\upmu }\)SXRD experiments. This work was supported by the National Science Foundation of China (51503186, 51803189) and Key Scientific Research Projects of Higher Education Institutions in Henan Province (21A430043).

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Authors and Affiliations

  1. National Center for International Joint Research of Micro-Nano Molding Technology, School of Mechanics and Engineering Science, Zhengzhou University, Zhengzhou, 450001, China

    Yanping Liu, Yingchao Wang, Mengnan Zhang, Zhiyuan Qi, Jun Zeng & Qian Li

  2. MOE Key Laboratory of Space Applied Physics and Chemistry, Shanxi Key Laboratory of Macromolecular Science and Technology, School of Science, Northwestern Polytechnical University, Xi’an, 710072, China

    Nan Tian

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  1. Yanping Liu
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  2. Yingchao Wang
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Correspondence to Yanping Liu or Nan Tian.

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Liu, Y., Wang, Y., Zhang, M. et al. A new insight into formation of 3D porous biomaterials. J Mater Sci 56, 3404–3413 (2021). https://doi.org/10.1007/s10853-020-05447-z

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