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The development and controversy of competitive endogenous RNA hypothesis in non-coding genes

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Abstract

As a momentous post-transcriptional regulator, microRNAs (miRNAs) are attracting more and more attention. The classical miRNAs regulated mechanism shows it binds to the targets’ 3′UTR thus play the role in post-transcription. Meanwhile, single miRNA can target multiple genes, so those should compete to bind that miRNA. Vice versa, single gene can sponge mass of miRNAs as well. Thus the competitive endogenous RNAs (ceRNAs) hypothesis was put forward in 2011. The ceRNA hypothesis has made huge achievements, in particular in non-coding genes, which including long non-coding RNAs (lncRNAs), circle RNAs (circRNAs) and pseudogenes, even viral transcripts. It also contributed greatly to epigenetics development. However, an increasing number of controversies have occurred with applause. Based on this situation, this review introduces something in detail about the ceRNAs hypothesis achieved in lncRNAs, circRNAs, pseudogenes and viral transcripts, respectively. Meanwhile, it also covers controversy of the ceRNAs hypothesis.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant numbers 31872334, 31902132).

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  1. Nanjing Agricultural University, Nanjing, China

    Weimin Lin, Hongcheng Liu, Yonghang Tang, Yuchen Wei, Wei Wei, Lifan Zhang & Jie Chen

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  1. Weimin Lin
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Lin, W., Liu, H., Tang, Y. et al. The development and controversy of competitive endogenous RNA hypothesis in non-coding genes. Mol Cell Biochem 476, 109–123 (2021). https://doi.org/10.1007/s11010-020-03889-2

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