Access to 2-pyridinylamide and imidazopyridine from 2-fluoropyridine and amidine hydrochloride†
Yibiao
Li, 
*a
Shiyong
Peng
a
and
*a
Shiyong
Peng
a
and
Abstract
Under catalyst-free conditions, an efficient method to synthesize 2-pyridinylamides has been developed, and the protocol uses inexpensive and readily available 2-fluoropyridine and amidine derivatives as the starting materials. Simultaneously, the copper-catalysed approach to imidazopyridine derivatives has been established with high chemoselectivity and regiospecificity. The results suggest that the nitrogen-heterocycles containing iodide substituents can also be compatible for the reaction via the cascade Ullmann-type coupling, and the nucleophilic substitution reaction provides the target products in a one-pot manner.
- This article is part of the themed collection: Synthetic methodology in OBC
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