Abstract
O-GlcNAcylation is an atypical, reversible, and dynamic glycosylation that plays a critical role in maintaining the normal physiological functions of cells by regulating various biological processes such as signal transduction, proteasome activity, apoptosis, autophagy, transcription, and translation. It can also respond to environmental changes and physiological signals to play the role of “stress receptor” and “nutrition sensor” in a variety of stress responses and biological processes. Even, a homeostatic disorder of O-GlcNAcylation may cause many diseases. Therefore, O-GlcNAcylation and its regulatory role in stress response are reviewed in this paper.
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This work was supported by grants from the General Project of National Natural Science Foundation of China (31972637, 31772695) and Key Project of Heilongjiang Natural Science Foundation (ZD2019C004).
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Yang Liu had the idea for the manuscript and wrote the manuscript. Rui-Zhi Yao performed the literature search. Shuai Lian and Peng Liu performed complementary literature searches. Ya-Jie Hu, Hong-Zhao Shi, and Hong-Ming Lv composed figures. Yu-Ying Yang corrected the manuscript for publication. Bin Xu and Shi-Ze Li supervised the work, evaluated the data, and approved the final version. All authors read and approved the final manuscript.
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Liu, Y., Yao, RZ., Lian, S. et al. O-GlcNAcylation: the “stress and nutrition receptor” in cell stress response. Cell Stress and Chaperones 26, 297–309 (2021). https://doi.org/10.1007/s12192-020-01177-y
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DOI: https://doi.org/10.1007/s12192-020-01177-y