Mitochondrial Dysfunction in Fragile-X Syndrome: Plugging the Leak May Save the Ship

doi:10.1016/j.molcel.2020.10.002

Molecular Cell

Volume 80, Issue 3, 5 November 2020, Pages 381-383

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Recent work by Licznerski et al. suggests that mutant FMRP linked to Fragile-X syndrome elevates the inner mitochondrial membrane proton leak, leading to increased metabolism and changes in protein synthesis that trigger impaired synaptic maturation and autistic behaviors.

Molecular Cell

SpotlightMitochondrial Dysfunction in Fragile-X Syndrome: Plugging the Leak May Save the Ship

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Mitochondrial Dysfunction in Fragile-X Syndrome: Plugging the Leak May Save the Ship