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A silver-coated copper wire as inexpensive drug eluting stent model: determination of the relative releasing properties of leoligin and derivatives

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Abstract

Cardiovascular diseases are overall the leading cause of mortality and morbidity worldwide. Therefore, treating and preventing coronary heart disease are of high scientific interest. Among several percutaneous coronary intervention procedures, coronary artery stenting displayed potent activity against restenosis, often observed using other invasive therapies. Nowadays, drug eluting stents’ superiority over bare metal stents is increasingly recognizable, since drug eluting stents are able to overcome problems encountered with bare metal stent technology. Within this study, we developed a novel method for performing drug-releasing experiments utilizing an affordable stent model made from a readily available silver-coated copper wire, which was further coated with poly(n-butyl methacrylate). Leoligin, previously reported to inhibit intimal hyperplasia and the regrowth of endothelial cells, was exploited along with several structural analogs in drug-releasing experiments. It was found that compounds exhibiting similar biological activity can have significantly different releasing properties, a crucial parameter to know for the selection of compounds for in vivo studies.

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Acknowledgements

This project was supported by the Austrian Wirtschaftsservice AWS (Austrian Promotional Bank) within the PRIZE Prototype Development Program (Z090391) and the Austrian Science Fund (FWF) within research grants S10710 and S10704 (NFN ‘Drugs from Nature Targeting Inflammation’). Financial support by the Austrian Agency for International Cooperation in Education & Research (OeAD-GmbH) to E.P. is gratefully acknowledged; E.P. is currently as associate fellow of the graduate school program Molecular Drug Targets MolTag (FWF Project W1232).

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Authors and Affiliations

  1. Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/163, 1060, Vienna, Austria

    Laszlo Czollner, Eleni Papaplioura, Thomas Linder, Michael Schnürch & Marko D. Mihovilovic

  2. Department of Pharmacognosy, University of Vienna, Althanstraße 14, 1090, Vienna, Austria

    Rongxia Liu, Yuanfang Li, Atanas G. Atanasov & Verena M. Dirsch

  3. School of Pharmacy, Yantai University, Yantai, 264005, People’s Republic of China

    Rongxia Liu

  4. Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, Munich, Germany

    Yuanfang Li

  5. Ludwig Boltzmann Institute for Digital Health and Patient Safety, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria

    Yuanfang Li & Atanas G. Atanasov

  6. Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzebiec, 05-552, Magdalenka, Poland

    Atanas G. Atanasov

  7. Institute of Neurobiology, Bulgarian Academy of Sciences, 23 Acad. G. Bonchevstr., 1113, Sofia, Bulgaria

    Atanas G. Atanasov

Authors
  1. Laszlo Czollner
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  2. Eleni Papaplioura
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  3. Thomas Linder
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  4. Rongxia Liu
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  5. Yuanfang Li
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  6. Atanas G. Atanasov
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  7. Verena M. Dirsch
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  8. Michael Schnürch
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  9. Marko D. Mihovilovic
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Corresponding author

Correspondence to Michael Schnürch.

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In memoriam Prof. Fritz Sauter.

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Czollner, L., Papaplioura, E., Linder, T. et al. A silver-coated copper wire as inexpensive drug eluting stent model: determination of the relative releasing properties of leoligin and derivatives. Monatsh Chem 154, 1317–1326 (2023). https://doi.org/10.1007/s00706-020-02677-4

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  • DOI: https://doi.org/10.1007/s00706-020-02677-4

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