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Rapid isolation and determination of bisphenol A in complicated matrices by magnetic molecularly imprinted electrochemical sensing

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Abstract

Because of its widespread distribution in the environment, bisphenol A (BPA) has become a global concern as an endocrine disruptor and a threat to human health through the food chain. Thus an efficient determination method is urgently needed for monitoring the levels of BPA. Herein, a novel electrochemical technique for the detection of BPA was performed by synchronous extraction and pre-concentration of BPA onto magnetic molecularly imprinted polymer (BMMIP), with subsequent readout on a magneto-actuated glassy carbon electrode (MGCE) by differential pulse voltammetry. Compared to the current methods of BPA determination, this BMMIP-based electrochemical sensor (BMMIPs@MGCE) not only simplifies the sample handling procedures substantially, without filtration, centrifugation, or other complex operations, but also can be easily renewed by a controllable magnetic field. As a sensor component, the core–shell BMMIPs exhibited excellent binding capacity (Qe = 82.5 mg g−1), short adsorption equilibrium time (30 s), and outstanding selectivity (k′ = 7.239) towards BPA, as well as stability and recyclability. Importantly, the BMMIPs@MGCE sensor was successfully applied for the on-site monitoring and rapid detection of BPA in complicated real-world specimens, with good recoveries (81.31–119.77%) and a low limit of detection (0.133 μmol L−1). Therefore, the stable and low-cost BMMIPs@MGCE sensor provides a new approach for the rapid determination of BPA in the field of environmental control and food safety.

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Acknowledgments

Financial support from the National Key Research and Development Program of China (2018YFC1602800), National Natural Science Foundation of China (21707070), and Natural Science Foundation of Jiangsu Province in China (BK20170998) are gratefully acknowledged. This work was also supported by the Young Talents Project in Jiangsu Province (2019) and Graduate Research and Innovation Projects of Jiangsu Province (KYCX20_1107).

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  1. Yi Chen Lu and Wei Wei Xiao contributed equally to this work.

Authors and Affiliations

  1. College of Food Science and Light Industry, Nanjing Tech University, Puzhu South Street No. 30, Nanjing, 211816, Jiangsu, China

    Yi Chen Lu, Wei Wei Xiao, Jun Yun Wang & Xiao Hui Xiong

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  1. Yi Chen Lu
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  2. Wei Wei Xiao
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  3. Jun Yun Wang
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Correspondence to Yi Chen Lu or Xiao Hui Xiong.

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Lu, Y.C., Xiao, W.W., Wang, J.Y. et al. Rapid isolation and determination of bisphenol A in complicated matrices by magnetic molecularly imprinted electrochemical sensing. Anal Bioanal Chem 413, 389–401 (2021). https://doi.org/10.1007/s00216-020-03006-8

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  • DOI: https://doi.org/10.1007/s00216-020-03006-8

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