Issue 4, 2021
From the journal:

Natural Product Reports

Natural products as modulators of retinoic acid receptor-related orphan receptors (RORs)

Angela Ladurner,†a   Patrik F. Schwarz†a  and  Verena M. Dirsch ORCID logo *a  

* Corresponding authors

a Department of Pharmacognosy, University of Vienna, Vienna, Austria
E-mail: Verena.Dirsch@univie.ac.at

Abstract

Covering: 1994 to 2020

Retinoic acid receptor-related orphan receptors (RORs) belong to a subfamily of the nuclear receptor superfamily and possess prominent roles in circadian rhythm, metabolism, inflammation, and cancer. They have been subject of research for over two decades and represent attractive but challenging drug targets. Natural products were among the first identified ligands of RORs and continue to be of interest to this day. This review focuses on ligands and indirect modulators of RORs from natural sources and explores their roles in a therapeutic context.

Graphical abstract: Natural products as modulators of retinoic acid receptor-related orphan receptors (RORs)

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Article information

DOI
https://doi.org/10.1039/D0NP00047G
Article type
Review Article
Submitted
02 Jul 2020
First published
29 Oct 2020
This article is Open Access
Creative Commons BY license

Nat. Prod. Rep., 2021,38, 757-781

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Natural products as modulators of retinoic acid receptor-related orphan receptors (RORs)

A. Ladurner, P. F. Schwarz and V. M. Dirsch, Nat. Prod. Rep., 2021, 38, 757 DOI: 10.1039/D0NP00047G

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