Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

CANCER EPIGENETICS

A ticking clock for B cell tumors

Nature Cancer volume 1, pages 1035–1037 (2020)Cite this article

Subjects

Tumor-specific changes in DNA methylation are both acquired actively through transcription-coupled processes and passively accumulated over time. Analysis across B cell malignancies now shows that these changes provide insight into the cellular origin as well as the proliferative history of tumors and thereby have diagnostic value and prognostic value, respectively.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: The epiCMIT clock.

References

  1. Seifert, M., Scholtysik, R. & Küppers, R. Methods Mol. Biol. 1956, 1–33 (2019).

    Article  CAS  Google Scholar 

  2. Oakes, C. C. & Martin-Subero, J. I. Blood 132, 999–1006 (2018).

    Article  CAS  Google Scholar 

  3. Duran-Ferrer, M. et al. Nat. Cancer https://doi.org/10.1038/s43018-020-00131-2 (2020).

  4. Lunning, M. A. & Green, M. R. Blood Cancer J. 5, e361 (2015).

    Article  CAS  Google Scholar 

  5. Kulis, M. et al. Nat. Genet. 47, 746–756 (2015).

    Article  CAS  Google Scholar 

  6. Mondello, P. et al. Cancer Discov. 10, 440–459 (2020).

    Article  CAS  Google Scholar 

  7. Sha, C. et al. J. Clin. Oncol. 37, 202–212 (2019).

    Article  CAS  Google Scholar 

  8. Figueroa, M. E. et al. J. Clin. Invest. 123, 3099–3111 (2013).

    Article  CAS  Google Scholar 

  9. Chapuy, B. et al. Nat. Med. 24, 679–690 (2018).

    Article  CAS  Google Scholar 

  10. Wright, G. W. et al. Cancer Cell 37, 551–568.e514 (2020).

    Article  CAS  Google Scholar 

  11. Horvath, S. & Raj, K. Nat. Rev. Genet. 19, 371–384 (2018).

    Article  CAS  Google Scholar 

  12. Shen, S. Y. et al. Nature 563, 579–583 (2018).

    Article  CAS  Google Scholar 

  13. Oakes, C. C. et al. Nat. Genet. 48, 253–264 (2016).

    Article  CAS  Google Scholar 

  14. Kretzmer, H. et al. Nat. Genet. 47, 1316–1325 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Lymphoma & Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Paolo Strati & Michael R. Green

  2. Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Paolo Strati

  3. Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Michael R. Green

Authors
  1. Paolo Strati
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael R. Green
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Michael R. Green.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Strati, P., Green, M.R. A ticking clock for B cell tumors. Nat Cancer 1, 1035–1037 (2020). https://doi.org/10.1038/s43018-020-00132-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s43018-020-00132-1

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer