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Synthesis of Benzofurans Modified by Coumarin and Pyrazole Heterocycles

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Chemistry of Natural Compounds Aims and scope

Reactions of 7-hydroxy-2-methyl-8-formylisoflavone with 4-chloromethylcoumarins synthesized 8-(coumarin-4-yl)furo[2,3-h]chromones, which reacted with 2-bromoacetylbenzofuran to produce 8-(benzofuroyl)furo [2,3-h]chromone. Recyclization of the corresponding furochromones through the action of hydrazine hydrate gave 4-hydroxybenzofurans with pyrazole and coumarin or benzofuroyl substituents.

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Authors and Affiliations

  1. Taras Shevchenko National University of Kiev, 64/13 Volodimirskaya St., Kiev, 01601, Ukraine

    T. V. Shokol, N. V. Gorbulenko & V. P. Khilya

  2. V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Murmanskaya St., Kiev-94, 02094, Ukraine

    M. S. Frasinyuk

Authors
  1. T. V. Shokol
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  2. N. V. Gorbulenko
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  3. M. S. Frasinyuk
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  4. V. P. Khilya
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Correspondence to T. V. Shokol.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2020, pp. 911–913.

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Shokol, T.V., Gorbulenko, N.V., Frasinyuk, M.S. et al. Synthesis of Benzofurans Modified by Coumarin and Pyrazole Heterocycles. Chem Nat Compd 56, 1060–1063 (2020). https://doi.org/10.1007/s10600-020-03226-5

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  • DOI: https://doi.org/10.1007/s10600-020-03226-5

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