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New Norneolignan and Bioactive Constituents of Clitoria ternatea

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Chemistry of Natural Compounds Aims and scope

A new norneolignan derivative, clitorternalactone (1), has been isolated from the stems of Clitoria ternatea, together with six known compounds, clitorienolactone A (2), myricetin 3-glucoside (3), quercetin 3-glucoside (4), kaempferol 3-glucoside (5), taraxerol (6), and taraxerone (7). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, compound 1 exhibited cytotoxicities with IC50 values of 2.54 ± 0.23, 3.68 ± 0.17, and 4.05 ± 0.43 μM, respectively, against DLD-1, CCRF-CEM, and IMR-32 cell lines. In addition, clitorternalactone (1), clitorienolactone A (2), quercetin 3-glucoside (4), and kaempferol 3-glucoside (5) showed potent inhibition with IC50 values of 3.05 ± 0.12, 5.44 ± 0.46, 10.20 ± 0.69, and 13.57 ± 0.36 μM, respectively, against LPS-induced NO generation.

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Acknowledgment

This research was supported by a grant from the Ministry of Science and Technology, Taiwan (MOST 106-2320-B-010-033-MY3), awarded to Prof. J.-J. Chen. This work was also supported by grants from Far Eastern Memorial Hospital–National Yang-Ming University Joint Research Program (108DN22), Medical Research Fund (No. 108-22) of Kaohsiung Armed Forces General Hospital, and Yuan’s General Hospital (YGH 19-027). Fu-Sen Wu, Ching-Ju Hung, and Chien-Liang Lin have contributed equally to this manuscript.

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Authors and Affiliations

  1. Department of Pharmacy, Far Eastern Memorial Hospital, 220, New Taipei City, Taiwan

    Fu-Sen Wu

  2. Department of Pharmacy, Yuan’s General Hospital, 802, Kaohsiung, Taiwan

    Ching-Ju Hung

  3. Department of Pharmacy, FooYin University Hospital, 928, Pingtung, Taiwan

    Chien-Liang Lin

  4. Institute of Microbiology and Immunology, National Defense Medical Center, 114, Taipei, Taiwan

    Tsung-Hsien Chang

  5. Department of Biological Sciences, National Sun Yat-Sen University, 804, Kaohsiung, Taiwan

    Chun-Lin Chen

  6. National Museum of Marine Biology and Aquarium, 944, Pingtung, Taiwan

    Ping-Jyun Sung

  7. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), 300, Hsinchu, Taiwan

    Ming-Jen Cheng

  8. Department of Pharmacy, Kaohsiung Armed Forces General Hospital, 802, Kaohsiung, Taiwan

    Hsueh-Yang Huang

  9. Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, 112, Taipei, Taiwan

    Jih-Jung Chen

  10. Department of Medical Research, China Medical University Hospital, 404, Taichung, Taiwan

    Jih-Jung Chen

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  1. Fu-Sen Wu
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  2. Ching-Ju Hung
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  3. Chien-Liang Lin
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  4. Tsung-Hsien Chang
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  5. Chun-Lin Chen
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  6. Ping-Jyun Sung
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  7. Ming-Jen Cheng
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  8. Hsueh-Yang Huang
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  9. Jih-Jung Chen
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Correspondence to Jih-Jung Chen.

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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2020, pp. 863–866.

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Wu, FS., Hung, CJ., Lin, CL. et al. New Norneolignan and Bioactive Constituents of Clitoria ternatea. Chem Nat Compd 56, 1000–1004 (2020). https://doi.org/10.1007/s10600-020-03213-w

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  • DOI: https://doi.org/10.1007/s10600-020-03213-w

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