Skip to main content
SpringerLink
Log in

Two New Flavones from Salvia plebeia and Their Anti-Angiogenic Activities

  • Published:
Chemistry of Natural Compounds Aims and scope

Two new flavones, namely 5-hydroxy-2-(4′-hydroxyphenyl)-6,12,13-trimethoxypyrano-xanthene-4,9-dione (1) and 5-hydroxy-2-(3′-methoxy-4′-hydroxyphenyl)-6-methoxy-11-isopropyl-pyranochromene-4,9-dione (2), were isolated from Salvia plebeia. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR spectral data. Compounds 1 and 2 were evaluated for their anti-angiogenic activities by the MTT assay with axitinib as positive control, and they displayed moderate anti-angiogenic activities with IC50 values of 14.07 and 11.25 μM, respectively.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. M. Akram, A. S. Syed, K. A. Kim, J. S. Lee, S. Y. Chang, C. Y. Kim, and O. N. Bae, J. Ethnopharmacol., 174, 322 (2015).

    Article  CAS  Google Scholar 

  2. M. R. Jin, H. Xu, C. H. Duan, and G. X. Chou, Nat. Prod. Res., 29, 1315 (2015).

    Article  CAS  Google Scholar 

  3. J. Xu, M. Wang, X. Sun, Q. Ren, X. Cao, S. Li, G. Su, M. Tuer-hong, D. Lee, Y. Ohizumi, M. Bartlam, and Y. Guo, J. Nat. Prod., 79, 2924 (2016).

    Article  CAS  Google Scholar 

  4. D. B. Ren, Y. H. Qin, Y. H. Yun, H. M. Lu, X. Q. Chen, and Y. Z. Liang, J. Sep. Sci., 37, 2118 (2014).

    Article  CAS  Google Scholar 

  5. A. Nugroho, M. H. Kim, J. Choi, N. I. Baek, and H. J. Park, Arch. Pharm. Res., 35, 1403 (2012).

    Article  CAS  Google Scholar 

  6. R. M. Lu, L. N. Pan, X. Y. Zhu, and Z. G. Zhong, Lishizheng Med. Mater. Med. Res., 19, 164 (2008).

    CAS  Google Scholar 

  7. S. K. Tripathi, R. K. Asthana, and A. Ali, Asian J. Chem., 18, 1554 (2006).

    CAS  Google Scholar 

  8. H. J. Jang, S. Lee, S. J. Lee, H. J. Lim, K. Jung, Y. H. Kim, S. W. Lee, and M. C. Rho, J. Nat. Prod., 80, 2666 (2017).

    Article  CAS  Google Scholar 

  9. S. Bang, T. K. Q. Ha, C. Lee, W. Li, W. K. Oh, and S. H. Shim, J. Ethnopharmacol., 192, 398 (2016).

    Article  CAS  Google Scholar 

  10. X. C. Weng and W. Wang, Food Chem., 71, 489 (2000).

    Article  CAS  Google Scholar 

  11. H. J. Jung, Y. S. Song, C. J. Lim, and E. H. Park, J. Ethnopharmacol., 126, 355 (2009).

    Article  Google Scholar 

  12. X. J. Qu, X. Xia, Y. S. Wang, M. J. Song, L. L. Liu, Y. Y. Xie, Y. N. Cheng, X. J. Liu, L. L. Qiu, L. Xiang, J. J. Gao, X. F. Zhang, and S. X. Cui, Food Chem. Toxicol., 47, 1710 (2009).

    Article  CAS  Google Scholar 

  13. Y. Q. Dai, L. Liu, G. Y. Xie, Y. J. Chen, X. Y. Qin, Q. Wang, J. Li, and M. J. Qin, Fitoterapia, 94, 142 (2014).

    Article  CAS  Google Scholar 

  14. Q. G. Ma, R. R. Wei, B. Zhou, Z. P. Sang, W. M. Liu, and Z. L. Cao, Nat. Prod. Res., 33, 457 (2019).

    Article  CAS  Google Scholar 

  15. M. R. Jin, H. Xu, C. H. Duan, and G. X. Chou, Nat. Prod. Res., 29, 1315 (2015).

    Article  CAS  Google Scholar 

  16. W. G. Wang, J. Wang, Y. Xu, H. T. Huang, W. L. Zeng, J. Li, W. S. Kong, X. Liu, G. Qian, G. Y. Yang, Q. F. Hu, and Y. K. Li, Chem. Nat. Compd., 55, 1018 (2019).

    Article  CAS  Google Scholar 

  17. R. R. Wei, Q. G. Ma, G. Y. Zhong, J. W. He, and Z. P. Sang, J. Ethnopharmacol., 253, 112685 (2020).

    Article  CAS  Google Scholar 

  18. R. R. Wei, Q. G. Ma, G. Y. Zhong, Y. L. Su, J. B. Yang, A. G. Wang, T. F. Ji, H. X. Guo, M. L. Wang, P. Jiang, and H. C. Wu, Phytochem. Lett., 35, 135 (2020).

    Article  CAS  Google Scholar 

  19. Q. G. Ma, R. R. Wei, D. L. Shang, Z.P. Sang, W. M. Liu, and Z. L. Cao, Pak. J. Pharm. Sci., 32, 2059 (2019).

    CAS  PubMed  Google Scholar 

  20. R. R. Wei, Q. G. Ma, G. Y. Zhong, M. Yang, and Z. P. Sang, Nat. Prod. Commun., 13, 1655 (2018).

    Google Scholar 

  21. D. S. Heo, J. G. Park, K. Hata, R. Day, R. B. Herberman, and T. L. Whiteside, Cancer Res., 50, 3681 (1990).

    CAS  PubMed  Google Scholar 

  22. R. R. Wei, Q. G. Ma, T. Li, W. M. Liu, Z. P. Sang, M. B. Li, and S. M. Liu, Bioorg. Chem., 77, 387 (2018).

    Article  CAS  Google Scholar 

  23. L. L. Fang, W. W. Lin, G. G. Qiu, Y. Cai, P. C. Yan, X. Q. Cai, W. C. Li, H. F. Tu, and J. Y. Dong, Phytochemistry, 120, 28 (2015).

    Article  CAS  Google Scholar 

Download references

Acknowledgment

This study was supported by the Doctoral Research Initiation Fund Project of Jiangxi University of TCM (2018BSZR007).

Author information

Authors and Affiliations

  1. Key Laboratory of Modern Preparation of TCM of Ministry of Education, Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine Jiangxi University of Traditional Chinese Medicine, 330004, Nanchang, Jiangxi, P. R. China

    Qinge Ma, Rongrui Wei, Qixin Lu, Haofeng Huang, Dongmei Guo & Lin Jiang

Authors
  1. Qinge Ma
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rongrui Wei
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Qixin Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Haofeng Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Dongmei Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Lin Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rongrui Wei.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2020, pp. 878–880.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ma, Q., Wei, R., Lu, Q. et al. Two New Flavones from Salvia plebeia and Their Anti-Angiogenic Activities. Chem Nat Compd 56, 1019–1022 (2020). https://doi.org/10.1007/s10600-020-03218-5

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10600-020-03218-5

Keywords

Search

Navigation