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Thermodynamic Properties of L-Methionine and Nicotinic Acid in an Aqueous Buffer Solution

  • PHYSICAL CHEMISTRY OF SOLUTIONS
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Abstract

Interaction between L-methionine (Met) and nicotinic acid (NA) in an aqueous buffer solution (pH 7.4) is studied via dissolution calorimetry and densimetry. The thermodynamic characteristics of the formation of a 1 : 1 molecular complex between Met and L at Т = 298.15 K are determined. The experimental density of the Met–L–buffer system is measured at T = 288.15, 298.15, 303.15, 308.15, and 313.15 K in the 0.0036 to 0.0367 mol/kg range of NA concentrations at a constant Met concentration (0.01249 mol/kg). It is shown that the extreme character of apparent molar volume–concentration dependences suggests the structure-strengthening effect NA has on solutions containing the amino acid (Met) with a slight shift of maxima with increasing temperature. The results are discussed in the context of the Gurney model.

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ACKNOWLEDGMENTS

This work is devoted to the memory of V.G. Badelin, Candidate of Chemistry and leading researcher of the Krestov Institute of Solution Chemistry, who supervised the beginning of these studies.

Density was measured on equipment at the shared resource center of the Upper Volga Regional Center of Physicochemical Studies, Krestov Institute of Solution Chemistry, Russian Academy of Sciences (http://www.isc-ras.ru/ru/struktura/ckp).

Funding

This study was supported by the Russian Foundation for Basic Research and the Government of Ivanovo oblast as part of scientific project no. 18-43-370018.

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Authors and Affiliations

  1. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, 153045, Ivanovo, Russia

    E. Yu. Tyunina, V. I. Smirnov & G. N. Tarasova

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  1. E. Yu. Tyunina
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  2. V. I. Smirnov
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  3. G. N. Tarasova
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Correspondence to E. Yu. Tyunina.

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Translated by E. Glushachenkova

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Tyunina, E.Y., Smirnov, V.I. & Tarasova, G.N. Thermodynamic Properties of L-Methionine and Nicotinic Acid in an Aqueous Buffer Solution. Russ. J. Phys. Chem. 94, 2238–2243 (2020). https://doi.org/10.1134/S003602442011031X

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  • DOI: https://doi.org/10.1134/S003602442011031X

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