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Implications of Biomolecular Corona for Molecular Imaging

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Abstract

The development of nanoparticle probes has opened up new possibilities for molecular imaging in the era of precision medicine. There are a wide range of nanoprobes that are being used for various modalities that have demonstrated promising potential in early detection, disease monitoring, and theranostics. However, the rate of successful clinical translation of the nanoprobes is very low and is affected by the lack of our understanding about nanoparticle interaction with biological fluids after systemic administration, thus representing an unmet clinical need. One of the poorly understood issues relates to the formation of biomolecular corona, a layer of biomolecules formed on the surface of nanoscale materials during their interactions with biological fluids. The biomolecular corona has several significant effects on the biodistribution of nanoprobes and their imaging ability by (i) reducing their targeting efficacy and (ii) affecting the intrinsic imaging properties (e.g., contrast capacity of magnetic nanoprobes). This review provides insights on the importance of considering biomolecular corona in the development of nanoprobes, which may enable their more efficient utilization for molecular imaging applications.

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Funding

This work was supported in part by R01CA135650 to A.M.

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  1. Morteza Mahmoudi and Anna Moore contributed equally to this work.

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  1. Precision Health Program, Michigan State University, East Lansing, MI, 48823, USA

    Morteza Mahmoudi & Anna Moore

  2. Department of Radiology, College of Human Medicine, Michigan State University, East Lansing, MI, 48823, USA

    Morteza Mahmoudi & Anna Moore

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M.M. participated in the conception and outline of the review as well as in manuscript writing. A.M. participated in literature search and analysis as well as in manuscript writing. Both authors accept responsibility and accountability for published work.

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Mahmoudi, M., Moore, A. Implications of Biomolecular Corona for Molecular Imaging. Mol Imaging Biol 23, 1–10 (2021). https://doi.org/10.1007/s11307-020-01559-9

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