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Dipeptide Mimetics of Different NGF and BDNF Loops Activate PLC-γ1

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

Previously, we designed and synthesized dipeptide mimetics of individual loops of the nerve growth factor (NGF) and the brain-derived neurotrophic factor (BDNF). It was shown that these mimetics activate the corresponding tyrosine kinase (Trk) receptors and have different patterns of activation of the PI3K/AKT and MAPK/ERK postreceptor signaling pathways in vitro. In the present study, it was shown on HT-22 cells that all these compounds activate the phospholipase C-γ1 (PLC-γ1) cascade.

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Authors and Affiliations

  1. Zakusov Research Institute of Pharmacology, Moscow, Russia

    T. A. Gudasheva, I. O. Logvinov, S. V. Nikolaev, T. A. Antipova, P. Yu. Povarnina &  S. B. Seredenin

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  1. T. A. Gudasheva
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  2. I. O. Logvinov
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  3. S. V. Nikolaev
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  4. T. A. Antipova
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  5. P. Yu. Povarnina
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  6. S. B. Seredenin
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Corresponding author

Correspondence to T. A. Gudasheva.

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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Translated by M. Batrukova

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Gudasheva, T.A., Logvinov, I.O., Nikolaev, S.V. et al. Dipeptide Mimetics of Different NGF and BDNF Loops Activate PLC-γ1. Dokl Biochem Biophys 494, 244–247 (2020). https://doi.org/10.1134/S1607672920050075

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  • DOI: https://doi.org/10.1134/S1607672920050075

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