Association between interleukin-10 gene polymorphisms and risk of oral carcinoma: A meta-analysis
Fan Li1,2, Xing Xu1,2, Chao Xuan3 and Wan-Tao Chen1,2
1Department of Oral Maxillofacial Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 2Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai and 3Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, China
Offprint requests to: Wan-Tao Chen MD PhD, Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Zhizaoju Road 639, Shanghai 200011, China. e-mail: chenwantao2002@hotmail.com or Chao Xuan MD PhD, Department of Clinical Laboratory, The Affiliated Hospital of Medical College, Qingdao University, No.59, Haier Road, Qingdao, 266101, China. e-mail: cxuan@qdu.edu.cn or bio-x.c@hotmail.com
Summary. Background. The single nucleotide polymorphisms (SNPs) of Interleukin-10 (IL-10) gene have been linked with the risk of oral carcinoma (OC) in a relatively small sample size. Our study aims to investigate the pooled associations by conducting a meta-analysis of published studies.
Methods. PubMed, Web of Science and Google Scholar databases were searched to identify eligible studies published in English before October 2019. The odds ratio (OR) with a 95% confidence interval (CI) was used to assess association. The publication bias was detected by Begg's test. Sensitivity and cumulative analyses were performed to evaluate the stability of crude results.
Results. The meta-analysis involved eight studies. Significant associations were certified between IL-10 gene -1082A/G polymorphism and susceptibility of OC for A vs. G (OR=1.817, 95% CI: 1.481-2.230), AA vs. GG (OR=3.436, 95% CI: 2.281-5.175), dominant genetic model (OR=2.913, 95% CI: 1.939-4.376), and recessive genetic model (OR=1.886, 95% CI: 1.372-2.594) in overall population, East Asians and South Asians. In addition, the significant association between -592A/C polymorphism of the gene and susceptibility of OC were detected in South Asians.
Conclusions. The meta-analysis results support that the IL-10 gene -1082G allele is a risk factor for OC in East Asians and South Asians, and IL-10 gene -592C allele is a protective factor for the disease. Histol Histopathol 35, 1329-1336 (2020)
Key words: Oral carcinoma, IL-10, Polymorphism, Meta-analysis
DOI: 10.14670/HH-18-275