ABSTRACT
Rigid and affine registrations to a common template are the essential steps during pre-processing of brain structural magnetic resonance imaging (MRI) data. Manual quality check (QC) of these registrations is quite tedious if the data contains several thousands of images. Therefore, we propose a machine learning (ML) framework for fully automatic QC of these registrations via local computation of the similarity functions such as normalized cross-correlation, normalized mutual-information, and correlation ratio, and using these as features for training of different ML classifiers. To facilitate supervised learning, misaligned images are generated. A structural MRI dataset consisting of 215 subjects from autism brain imaging data exchange is used for 5-fold cross-validation and testing. Few classifiers such as kNN, AdaBoost, and random forest reached testing F1-scores of 0.98 for QC of both rigid and affine registrations. These tested ML models could be deployed for practical use.
Competing Interest Statement
The authors have declared no competing interest.
Footnotes
Existing equations (2), (3) and (4) are updated. Extra equation (5) is added. Authors list is updated with new affiliations. Lastly, github link is provided.