Abstract
Purpose
To determine whether maternal age has an impact on monozygotic twinning (MZT) rates in women undergoing single embryo transfer (SET).
Methods
This is a retrospective cohort study analyzed for the incidence of MZT of all clinical pregnancies after a single embryo transfer was carried out between 2014 and 2018. The effect of different assisted reproductive technology (ART) parameters on the incidence of MZT was evaluated.
Results
There were a total of 8459 cycles resulting in pregnancy during the study period. Of these pregnancies, 8236 were singletons and 223 were MZT. The preterm birth rate, miscarriage rate, and cesarean section rate were higher in MZT. Birth weight and gestational age at delivery were lower and smaller. In the univariate analysis, the risk of MZT was decreased with frozen embryo transfer (ET). A nonlinear relationship was observed between maternal age and MZT. A negative relationship between maternal age and MZT was observed in the patients’ age ≥ 36 years.
Conclusion
Advanced maternal age was associated with a lower rate of MZT. A threshold female age of 36 years existed for lower MZT.
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This study was approved by the ethics committee of the Northwest Women’s and Children’s Hospital (number 2018002). Because of the nature of the retrospective cohort study, informed consent was therefore waived.
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Liu, X., Shi, J. Maternal age is associated with embryo splitting after single embryo transfer: a retrospective cohort study. J Assist Reprod Genet 38, 79–83 (2021). https://doi.org/10.1007/s10815-020-01988-z
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DOI: https://doi.org/10.1007/s10815-020-01988-z