Abstract
An integrated microscopic study of the destruction of mouse Ehrlich ascites carcinoma (EAC) cells under starvation conditions has been carried out. It has been found that, in addition to apoptosis, necrosis, and apoptotic necrosis, already known for EAC, cell destruction can also occur through mitochondrial autolysis, which is proposed to be considered a new kind of mitoptosis. A mitoptosis in EAC is characterized by the appearance of many autolyzing mitochondria, the fusion of which leads to rupture of the cell membrane and the ejection of the nucleus from the cell. It is assumed that the polymorphism of EAC destruction patterns is explained by the different physiological state of the cells, which determines the “choice” of the cell death mechanism. This situation poses a challenge for researchers to develop complex inducers with the ability to stimulate all possible types of cancer cell death.
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ACKNOWLEDGMENTS
We are grateful to D.V. Fomin for the help in using the equipment of the Center for Shared Use of the NSCMB FEB, Russian Academy of Sciences (Vladivostok, Russia). Part of the study was carried out at the Electron Microscopy Laboratory of the University of St. Francis Xavier (Antigonish, Nova Scotia, Canada).
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Pimenova, E.A., Reunova, Y.A., Menchinskaya, E.S. et al. An Unusual Pathway of Mitoptosis Found in Ehrlich Carcinoma Cells. Dokl Biol Sci 494, 240–243 (2020). https://doi.org/10.1134/S0012496620050063
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DOI: https://doi.org/10.1134/S0012496620050063