Regioselective synthesis and antioxidant activity of a novel class of mono and C₂-symmetric bis-1,2,3-triazole and acridinedione grafted macromolecules

Abstract

An expedient regioselectivesynthesis of novel mono, C₂-symmetric bis-triazole and acridinedione bridged macromolecules has been achieved in good yields employing intermolecular Cu(I) catalyzed azide and alkyne click reaction. Synthesis of O-propargyl acridinedione was achieved in three good yielding steps starting from dimedone, while the symmetrical aliphatic and aryl bis-azides were derived from appropriate dibromides in the presence of sodium azide in dry DMF. The synthesized mono and C₂-symmetric bis-macromolecules have been elucidated by ¹H, ¹³C, elemental and mass spectroscopic analysis. The antioxidant activity of synthesized compounds has also been investigated.