NLRP3 inflammasome upregulates PD-L1 expression and contributes to immune suppression in lymphoma
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Keywords
Diffuse large B cell lymphoma
NLRP3
Interleukin-18
Immune checkpoints
Immunosuppression
Abbreviations
Caspase-1
Cysteine-requiring Aspartate Protease-1
DLBCL
diffuse large B-cell lymphoma
ELISA
enzyme-linked immunosorbent assay
Foxp3
forkhead box P3
ICB
Immune checkpoint blockade
IFN-γ
interferon-γ
IL-1β
interleukin-1β
IL-18
interleukin-18
LAG-3
lymphocyte-activation gene 3
MDSCs
myeloid-derived suppressor cells
NHL
non-Hodgkin lymphoma
NLRP3
Nod-like receptor pyrin domain 3
PD-1
programmed cell death protein 1
PD-L1
programmed cell death ligand 1
p-STAT3
phosphorylated STAT3
STAT
signal transducers and activators of transcription
TAM
tumor-associated macrophage
TIM-3
T cell immunoglobulin domain and mucin domain-3
TME
tumor microenvironment
TNF-α
tumor necrosis factor-α
Treg
regulatory T cell
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These authors contributed equally to this work.
© 2020 The Authors. Published by Elsevier B.V.