Abstract
We investigated the effects of the H2S and CO gasomediators on Ca2+-dependent potassium channels and an anion exchanger, which participate in the induction of the hyperpolarization response of the erythrocyte membrane and play an important role in regulation of the volume and deformability of erythrocytes. We showed that in the presence of H2S and CO donors, the amplitude of the redox-stimulated membrane hyperpolarization decreased significantly due to a decrease in the activity of Ca2+-dependent potassium channels. It was found that H2S and CO eliminate the compression of erythrocytes observed during activation of Ca2+-dependent potassium channels or inhibition of the anion exchanger. It was shown that the H2S donor significantly increases the erythrocyte deformability.
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Funding
This study was carried out with financial support from the Russian Foundation for Basic Research (within the framework of scientific project no. 19-415-703015) and the Council for Grants of the President of the Russian Federation (grant MK-143.2020.4).
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The authors declare no conflicts of interest.
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This work followed the ethical standards developed in accordance with the Declaration of Helsinki (as amended in 2013) and the Rules of Good Clinical Practice (order of the Ministry of Health of the Russian Federation of 01.04.2016). All individuals participating in the study gave informed consent.
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Translated by I. Shipounova
Abbreviations: КСа-channels, Са2+-dependent potassium channels; PMS, phenazine metasulfate; CORM-2, tricarbonyldichlororuthenium(II) dimer; HR, hyperpolarizing response.
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Petrova, I.V., Birulina, Y.G., Belyaeva, S.N. et al. The Effects of Gasomediators on the Са2+-Dependent Potassium Permeability of the Erythrocyte Membrane. BIOPHYSICS 65, 614–618 (2020). https://doi.org/10.1134/S0006350920040156
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DOI: https://doi.org/10.1134/S0006350920040156