Abstract
Radical chemistry is tightly interwoven in proposed prebiotic synthetic pathways, reaction networks and geochemical scenarios that have helped shape our understanding of how life could have originated. Gas-phase prebiotic reactions involving electric discharge, vapour ablation by asteroidal and cometary impacts as well as ionising radiation all produce radicals that facilitate complex molecular synthesis. Reactions in the solid phase which are responsible for astrochemical syntheses can also take place through radicals produced via irradiation of protoplanetary/interstellar ice grains and dust particles. Aqueous-phase radical chemistry affords further molecular complexity promoting the production of precursors for the synthesis of biopolymers thought important for the emergence of life. Radical chemistry appears to be a common thread amongst all kinds of prebiotic investigations, and this Review aims to bring attention to a few selected examples. Some important historical studies and modern developments with respect to prebiotic chemistry are summarised through the lens of radical chemistry.
Funding source: UNSW’s Strategic Hires and Retention Pathways (SHARP)
About the author
Albert C. Fahrenbach received his BS in Chemistry from Indiana University in 2008, having done research under the tutelage of Professor Amar Flood in synthetic and supramolecular chemistry. He received his PhD from Northwestern University in Organic Chemistry in 2013 under the mentorship of Professor Sir Fraser Stoddart investigating the molecular self-assembly and template-directed syntheses of artificial molecular switches and machines. Albert then moved to Boston to carry out research in origins-of-life chemistry as a postdoctoral scholar with Professor Jack Szostak at Harvard University and Massachusetts General Hospital. As part of a unique Fellowship opportunity during this time, Albert also spent three months of the year at the Tokyo Institute of Technology in the Earth-Life Science Institute (ELSI), a research centre which specialises in origins-of-life research. Thereafter, Albert spent a year with ELSI as an Associate Principal Investigator before moving in 2018 to the University of New South Wales, where he currently resides as a Lecturer in the School of Chemistry. He is an awardee of the 2014 IUPAC-Solvay International Award for Young Chemists.
Acknowledgments
The authors would like to acknowledge UNSW’s Strategic Hires and Retention Pathways (SHARP) for support. We would also like to thank the editor for the invitation to submit to this Diamond Jubilee special issue.
Research funding: This research was supported by the UNSW’s Strategic Hires and Retention Pathways (SHARP).
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