Original ResearchFibrinogen/AKT/Microfilament Axis Promotes Colitis by Enhancing Vascular Permeability
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Graphical abstract
Keywords
Fibrinogen
Vascular Permeability
Colitis
GPRP Acetate
Abbreviations used in this paper
DSS
dextran sulfate sodium
eNOS
endothelial nitric oxide synthase
Fg
fibrinogen
GPRP
Gly-Pro-Arg-Pro acetate
IBD
inflammatory bowel disease
IFN-γ
interferon gamma
IL
interleukin
p-AKT
phosphorylated AKT
TNF-α
tumor necrosis factor alpha
TNBS
trinitrobenzene sulfonic acid
TUNEL
terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick-end labeling
UC
ulcerative colitis
VEGF
vascular endothelial growth factor
VP
vascular permeability
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Conflicts of Interest The authors disclose no conflicts.
Funding This study was supported by grants from the Key Scientific Research Project of Colleges in Education Department of Guangdong Province (2018KZDXM057, J.Y.), the National Science and Technology Major Project of China (2016ZX08011-005, A.T.), Overseas Expertise Introduction Center for Discipline Innovation (111 center, D18010, J.Y.), Youth Program of Guangxi Natural Science Foundation of China (2019JJB140217, C.Z.), and Special Project Guangxi Science and Technology Base and Talent (2019AC20274, C.Z.).
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Authors share co-first authorship.
© 2021 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.