2-Oxo-2,5,6,7-tetrahydro-3-cyano-1H-cyclopenta[b]pyridine was used as the starting point to develop an accessible synthesis of condensed cyclopentanopyrido[3',2':4,5]thieno[3,2-d]pyrimidine derivatives. The neurotropic activity of these compounds was studied, and a number of them showed anticonvulsant activity as antagonism to corasol. Compound II, like diazepam, had anti-anxiety and activating effects, while the other compounds had sedative activity.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 7, pp. 27 – 32, July, 2020.
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Dabaeva, V.V., Bagdasaryan, M.R., Paronikyan, E.G. et al. Synthesis and Neurotropic Activity of Novel Condensed Cyclopentanopyrido[3',2':4,5]-Thieno[3,2-D]Pyrimidine Derivatives. Pharm Chem J 54, 707–713 (2020). https://doi.org/10.1007/s11094-020-02259-y
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DOI: https://doi.org/10.1007/s11094-020-02259-y