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RETRACTED ARTICLE: Long noncoding RNA LINC00460 promotes the progression of cervical cancer via regulation of the miR-361-3p/Gli1 axis

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This article was retracted on 18 May 2022

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Abstract

Mounting evidence indicates that the long non-coding RNA (lncRNA) LINC00460 plays an oncogenic role in tumor progression; however, the role of LINC00460 in cervical cancer (CC) remains unknown. In this study, we found that LINC00460 was frequently upregulated in CC tissues and cell lines. Knockdown of LINC00460 repressed CC cell growth and invasion in vitro and attenuated tumorigenesis in vivo. Mechanistically, miR-361-3p was predicted as a direct target of LINC00460 by bioinformatics analysis, which was further confirmed by qRT-PCR, dual-luciferase reporter assays, and rescue experiments. Furthermore, miR-361-3p targeted the 3′ untranslated region (UTR) of Gli1 mRNA and repressed its expression. Taken together, our study revealed that LINC00460 functions as an oncogenic lncRNA in CC, indicating the likely participation of the LINC00460/miR-361-3p/Gli1 pathway in the disease. Accordingly, our results provide new insight into CC tumorigenesis.

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Data availability

The analyzed data sets generated during the study are available from the corresponding author on reasonable request.

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Acknowledgements

The study was supported by the Special Fund for Gynecology and Obstetrics of Medical Association Disease Diagnosis and Freatment Center of Shanghai Sixth People’s Hospital (02.LY01.03.23).

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Authors and Affiliations

  1. Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Gusu District, Suzhou, 215000, China

    Fan Li & Weipei Zhu

  2. Department of Gynaecology and Obestetrics, Shanghai the Eighth People’s Hospital, No.8 Caobao Road, Xuhui District, Shanghai, 200235, China

    Fan Li & Zhijie Wang

Authors
  1. Fan Li
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  2. Weipei Zhu
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  3. Zhijie Wang
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Contributions

FL, WZ and ZW conceived and designed this study. FL, WZ and ZW collected the samples and performed the experiment. FL wrote the paper. WZ and ZW revised the manuscript. All authors read and approved the final manuscript.

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Correspondence to Weipei Zhu or Zhijie Wang.

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The authors declare that there is no conflict of interest regarding the publication of this paper.

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The present study was approved by the Ethics Committee of Shanghai the Eighth People’s Hospital, and written informed consent for use of the specimens for research purposes was obtained from each patient.

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This article has been retracted. Please see the retraction notice for more detail:https://doi.org/10.1007/s13577-022-00723-3

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Li, F., Zhu, W. & Wang, Z. RETRACTED ARTICLE: Long noncoding RNA LINC00460 promotes the progression of cervical cancer via regulation of the miR-361-3p/Gli1 axis. Human Cell 34, 229–237 (2021). https://doi.org/10.1007/s13577-020-00447-2

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  • DOI: https://doi.org/10.1007/s13577-020-00447-2

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