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Comparative Study of the Dose-Dependent Effects of the Osmoregulators Sorbitol and Mannitol in Asaparkam-L on Diuresis and Saluresis in Rats

  • MOLECULAR BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTION
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Pharmaceutical Chemistry Journal Aims and scope

The effects of the osmoregulators D-sorbitol and D-mannitol in Asparkam-L solution for infusion on diuresis and urinary K+ and Mg2+ excretion were studied in white mongrel rats. Animals received single i.v. doses of samples of the formulation Asparkam-L: 1) with osmoregulator D-sorbitol; 2) with osmoregulator D-mannitol, 3) without osmoregulator, at the recommended one-time dose (1ROTD, calculated from the dose of 10 ml for a human with the average body weight of 70 kg) and at doses 2, 4, and 6 times greater than 1ROTD. Use of all study doses produced a background of minor oscillations in diuresis, with the smallest levels of urinary K+ and Mg2+ excretion with sample 1 and the largest with sample 2. Levels of K+ and Mg2+ excretion in rats given sample 2 were statistically significantly greater than those in control animals given 0.89% NaCl at a volume equivalent to that of 6 ROTD. Increased K+ and Mg2+ excretion after use of sample 2 probably indicated lower efficacy and the inadvisability of using mannitol as osmoregulator in the formulation intended to make up for deficit of these cations.

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Authors and Affiliations

  1. Volgograd State Medical University, Ministry of Health of the Russian Federation, 1 Pavshikh Bortsov Square, 400131, Volgograd, Russia

    A. A. Spasov

  2. Science Center for Innovatory Drugs and Pilot-Scale Production, Volgograd, Russia

    L. I. Bugaeva, V. V. Bagmetova, S. A. Lebedeva & A. Yu. Getmanenko

  3. Astrakhan State Medical University, Ministry of Health of the Russian Federation, 121 Bakinskaya Street, 414000, Astrakhan, Russia

    V. V. Bagmetova

Authors
  1. A. A. Spasov
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  2. L. I. Bugaeva
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  3. V. V. Bagmetova
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  4. S. A. Lebedeva
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  5. A. Yu. Getmanenko
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Correspondence to V. V. Bagmetova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 7, pp. 3 – 9, July, 2020.

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Spasov, A.A., Bugaeva, L.I., Bagmetova, V.V. et al. Comparative Study of the Dose-Dependent Effects of the Osmoregulators Sorbitol and Mannitol in Asaparkam-L on Diuresis and Saluresis in Rats. Pharm Chem J 54, 667–672 (2020). https://doi.org/10.1007/s11094-020-02254-3

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  • DOI: https://doi.org/10.1007/s11094-020-02254-3

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