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Microstructure, mechanical properties, and in vitro behavior of biodegradable Zn-1Mg-0.1Ca and Zn-1Mg-0.5Ca

  • Biomaterials Synthesis and Characterization
  • Original Research
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Abstract

In the present study, the microstructure, mechanical properties, corrosion behavior, wettability, haemocompatibility, and cytocompatibility of the as-cast and as-rolled biodegradable Zn-1Mg-0.1Ca and Zn-1Mg-0.5Ca have been systematically investigated to evaluate their feasibility as potential biodegradable materials. The results demonstrated that the Zn-1Mg-0.1Ca have significantly improved mechanical properties, with the yield strength (YS), ultimate tensile strength (UTS), and elongation of as-rolled Zn-1Mg-0.1Ca are (209.04 ± 28.31) MPa, (331.51 ± 40.06) MPa, and (35.43 ± 3.53)%, respectively. Wettability test results demonstrated that the Zn-1Mg-0.1Ca and Zn-1Mg-0.5Ca have hydrophilic surfaces that can enhance cell responses and tissue-implant interactions. The haemocompatibility evaluation showed that the hemolysis ratio of Zn-1Mg-0.1Ca have a low hemolysis ratio of 0.6%; the platelets remain sphere morphology and are not activated. High cell viability indicates the cytocompatibility of the as-rolled Zn-1Mg-0.1Ca alloy. The Zn-1Mg-0.1Ca alloy can be considered as new suitable biodegradable Zn-based alloys for further biomedical applications.

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Acknowledgements

The present work was supported by the National Natural Science Foundation of China (No. 31700819), the Young Elite Scientists Sponsorship Program by CAST (YESS, No.2018QNRC001), the research funds of Lepu Medical Technology (Beijing) Co., Ltd and the Fundamental Research Funds for the Central Universities (No. 06500098).

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  1. These authors contributed equally: Huafang Li, Chao Shen

Authors and Affiliations

  1. School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China

    Huafang Li

  2. Department of Orthopedic Surgery, The Sixth Medical Center of PLA General Hospital, Beijing, 100048, China

    Chao Shen & Dike Ruan

  3. Department of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, China

    Chao Shen, Xiaokang Li, Shuo Guo & Zheng Guo

  4. Lepu Medical Technology Co., Ltd, Beijing, 102200, China

    Xiwei Liu

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  1. Huafang Li
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Correspondence to Huafang Li, Xiwei Liu or Zheng Guo.

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Li, H., Shen, C., Ruan, D. et al. Microstructure, mechanical properties, and in vitro behavior of biodegradable Zn-1Mg-0.1Ca and Zn-1Mg-0.5Ca. J Mater Sci: Mater Med 31, 88 (2020). https://doi.org/10.1007/s10856-020-06444-z

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