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Biological and Chemical Assessment of Ochrosia elliptica Labill Leaves

  • Research Article-Biological Sciences
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Abstract

Ochrosia elliptica Labill is a small tropical evergreen tree native to Oceania belonging to the Apocynaceae family. Eight alkaloids, two flavonoid glycosides and three phenolic acids were identified by LC/MS analysis. On the other hand, the quality and uniformity of the plant leaves were assessed through the determination of the total phenolic and flavonoid, in addition to total ash, acid-insoluble ash, water-soluble ash and moisture content. The total ethanolic and aqueous extracts of the leaves of O. elliptica as well as their fractions were investigated for their antinociceptive (analgesic) using tail-flick test and antimicrobial activities using agar well diffusion assay. Among the tested fractions, the results showed that the n-butanol fraction exhibited high potency as antinociceptive compared to indomethacin drug and as antifungal compared to amphotericin B.

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This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, El-Kasr El-Aini St, P.B. 11562, Cairo, Egypt

    Riham A. El-Shiekh, Dalia A. Al-Mahdy, Mohamed S. Hifnawy & Essam Abdel-Sattar

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  1. Riham A. El-Shiekh
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  2. Dalia A. Al-Mahdy
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  3. Mohamed S. Hifnawy
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  4. Essam Abdel-Sattar
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All authors contributed equally to this study (study design, experimental work, data analysis, manuscript writing).

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Correspondence to Essam Abdel-Sattar.

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El-Shiekh, R.A., Al-Mahdy, D.A., Hifnawy, M.S. et al. Biological and Chemical Assessment of Ochrosia elliptica Labill Leaves. Arab J Sci Eng 46, 5247–5255 (2021). https://doi.org/10.1007/s13369-020-04986-6

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  • DOI: https://doi.org/10.1007/s13369-020-04986-6

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