Priority data have been obtained on the effects of repeated systemic administrations of water-dispersible single-walled carbon nanotubes (SWCNTs) to spontaneously hypertensive rats with respect to constitutive NO-synthase (cNOS). As is known, NO is an inhibitory transmitter in the cardiovascular system. It was found that the systemic (i.p., subcutaneous, and i.m.) introductions of SWCNTs during two weeks resulted in considerable elevations of the NO2– level (a marker of NO bioavailability) in the blood of experimental hypertensive animals. Thus, SWCNTs may be used in the future for antihypertensive therapy as a novel agent capable of activating cNOS and, thus, increasing the NO production in central and peripheral elements of the cardiovascular system.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
O. P. Matyshevska, A. Yu. Karlash, Ya. V. Shtogun, et al., “Self-organizing DNA/carbon nanotube molecular films,” Mater. Sci. Eng. C, 15, No. 1–2, 249-252 (2001).
V. R. Raphey, T. K. Henna, K. P. Nivitha, et al., “Advanced biomedical applications of carbon nanotube,” Mater. Sci. Eng. C Mater. Biol. Appl., 100, 616–630 (2019).
R. Vidu, M. Rahman, M. Mahmoudi, et al., “Nanostructures: a platform for brain repair and augmentation,” Front. Syst. Neurosci., 8, 91 (2014).
W. Zhou, Y. Y. Wang, T. S. Lim, et al., “Detection of single ion channel activity with carbon nanotubes,” Sci. Rep., 5, 9208 (2015).
H. J. Lee, J. Park, O. J. Yoon, et al., “Amine-modified single-walled carbon nanotubes protect neurons from injury in a rat stroke model,” Nat. Nanotechnol., 6, No. 2, 121–125 (2011).
K. T. Al-Jamal, L. Gherardini, G. Bardi, et al., “Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing,” Proc. Natl. Acad. Sci. USA, 108, No. 27, 10952–10957 (2011).
V. Martinelli, G. Cellot, A. Fabbro, et al., “Improving cardiac myocytes performance by carbon nanotubes platforms,” Front. Physiol., 4, 239 (2013).
J. M. Gutierrez-Hemandez, M. A. Ramirez-Lee, H. Ro- sas-Hermandez, et al., “Single-walled carbon nanotubes (SWCNTs) induce vasodilation in isolated rat aortic rings,” Toxicol. in Vitro, 29, No. 4, 657–662 (2015).
J. M. Lagramante, S. Sacco, P. Crobeddu, et al, “Changes in cardiac autonomic regulation after acute lung exposure to carbon nanotubes: implications for occupational exposure,” J. Nanomater., 2012, ID 397206 (2012).
N. V. Radchenko, Y. Prylutskyy, L. M. Shapoval, and V. Sagach, “Impact of single-walled carbon nanotubes on the medullary neurons in spontaneously hypertensive rats,” Mat. Wiss. Werkstofftech., 44, Nos. 2–3, 171–175 (2013).
S. Prylutska, R. Bilyy, T. Shkandina, et al., “Сomparative study of membranotropic action of single- and multi-walled carbon nanotubes,” J. Biosci. Bioeng., 115, No. 6, 674–679 (2013).
N. Oh and J. H. Park, “Endocytosis and exocytosis of nanoparticles in mammalian cells,” Int. J. Nanomed., 9, Suppl 1, 51–63 (2014).
L. Lacerda, J. Russier, G. Pastorin, et al., “Translocation mechanisms of chemically functionalised carbon nanotubes across plasma membranes,” Biomaterials, 33, No. 11, 3334–3343 (2012).
L. M. Shapoval, S. V. Prylutska, A. V. Kotsyuruba, et al., “Single-walled carbon nanotubes modulate cardiovascular control in rats,” Mat. Wiss. Werkstofftech., 47, Nos. 2–3, 208–215 (2016).
U. Ritter, P. Scharff, O. P. Dmytrenko, et al. “Radiation damage and Raman vibrational modes of single-walled carbon nanotubes,” Chem. Phys. Lett., 447, Nos. 4–6, 252–256 (2007).
V. F. Korolovych, L. A. Bulavin, Yu. I. Prylutskyy, et al., “Influence of single-walled carbon nanotubes on the thermal expansion of water,” Int. J. Thermophys., 35, 19–31 (2014).
J. Sun, X. Zhang, M. Broderick, and H. Fein, “Measurement of nitric oxide production in biological systems by using Griess reaction assay,” Sensors, 3, No. 8, 276–284 (2003).
S. Y. Chin, K. N. Pandey, S. J. Shi, et al., “Increased activity and expression of Ca2+-dependent NOS in renal cortex of ANG II-infused hypertensive rats,” Am. J. Physiol., 277, 797–804 (1999).
V. M. Harik, “Geometry of carbon nanotubes and mechanisms of phagocytosis and toxic effects,” Toxicol. Lett., 273, 69–85 (2017).
H. Kafa, J. T.-W. Wang, N. Rubio, et al. “The interaction of carbon nanotubes with an in vitro blood-brain barrier model and mouse brain in vivo,” Biomaterials, 53, 437–452 (2015).
L. N. Shapoval, O. V. Dmytrenko, L. S. Pobegailo, et al., “Hemodynamic responses induced by modulation of the nitric oxide system and mitochondrial permeability in the medullary cardiovascular nuclei of rats,” Neurophysiology, 39, 232–244 (2007).
N. Toda, K. Ayajiki, and T. Okamura, “Control of systemic and pulmonary blood pressure by nitric oxide formed through neuronal nitric oxide synthase,” J. Hypertens., 27, 1929–1940 (2009).
S. V. Prylutska, I. I. Grynyuk, S. M. Grebinyk, et al., “Comparative study of biological action of fullerenes C60 and carbon nanotubes in thymus cells,” Mat. Wiss. Werkstofftech., 40, No. 4, 238–241 (2009).
O. H. Minchenko, D. O. Tsymbal, D. O. Minchenko, et al., “Single-walled carbon nanotubes affect the expression of genes associated with immune response in normal human astrocytes,” Toxicol. In Vitro, 52, 122–130 (2018).
S. V. Prylutska, I. I. Grynyuk, O. P. Matyshevska, et al., “Estimation of multi-walled carbon nanotubes toxicity in vitro,” Physica E Low-Dimens. Syst. Nanostruct., 40, No. 7, 2565–2569 (2008).
R. Singla, C. Sharma, A. K. Shukla, and A. Acharya, “Toxicity concerns of therapeutic nanomaterials,” J. Nanosci. Nanotechnol., 19, No. 4, 1889–1907 (2019).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Shapoval, L.M., Dmytrenko, O.V., Sagach, V.F. et al. Systemic Administrations of Water-Dispersible Single-Walled Carbon Nanotubes: Activation of NOS in Spontaneously Hypertensive Rats. Neurophysiology 52, 101–109 (2020). https://doi.org/10.1007/s11062-020-09858-1
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11062-020-09858-1