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A rare case of cutaneous Papiliotrema (Cryptococcus) laurentii infection in a 23-year-old Caucasian woman affected by an autoimmune thyroid disorder with hypothyroidism

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Abstract

In recent years, the frequency of infections due to saprophytic fungi has increased. Cryptococcus laurentii, recently classified as Papiliotrema laurentii, is responsible for fungemia, meningitis, and superficial infections. Here, we report the first case of cutaneous Papiliotrema (Cryptococcus) laurentii infection in a 23-year-old Caucasian woman affected by an autoimmune thyroiditis with hypothyroidism. Impairments of the immune system are often associated with unusual fungal infections, which cannot be neglected. The isolate strain was susceptible to Amphotericin B while resistant to fluconazole, itraconazole, voriconazole, and terbinafine. The patient was successfully treated with Amphotericin B.

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Acknowledgments

We gratefully acknowledge personnel of Hospital of Desio for technical support. We also thank Dr. Elena Intra for reviewing the manuscript.

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Authors and Affiliations

  1. Clinical Chemistry Laboratory, University of Milano-Bicocca, Azienda Socio Sanitaria Territoriale di Monza ASST-Monza, St Gerardo Hospital, via Pergolesi 33, 20900, Monza, Monza and Brianza, Italy

    J. Intra

  2. Department of Laboratory Medicine, University of Milano-Bicocca, Azienda Socio Sanitaria Territoriale di Monza ASST-Monza, Desio Hospital, via Mazzini 1, 20833, Desio, Monza and Brianza, Italy

    C. Sarto & P. Brambilla

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  1. J. Intra
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  2. C. Sarto
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  3. P. Brambilla
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Correspondence to J. Intra.

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Intra, J., Sarto, C. & Brambilla, P. A rare case of cutaneous Papiliotrema (Cryptococcus) laurentii infection in a 23-year-old Caucasian woman affected by an autoimmune thyroid disorder with hypothyroidism. Eur J Clin Microbiol Infect Dis 40, 647–650 (2021). https://doi.org/10.1007/s10096-020-04058-5

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  • DOI: https://doi.org/10.1007/s10096-020-04058-5

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