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Fabrication of homogeneous waffle-like silver composite substrate for Raman determination of trace chloramphenicol

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Abstract

Waffle-like anodized aluminum oxide homogeneously immobilized with Ag nanoparticles (AAO/Ag) is rationally designed and fabricated as surface-enhanced Raman scattering (SERS) substrate. The as-prepared SERS substrate is characterized with transmission electron microscope (TEM), scanning electron microscopy (SEM), UV–Vis spectrophotometer, and Fourier transform infrared spectrometer (FT-IR). The AAO/Ag substrate shows good uniformity of the Raman signals (RSD = 7.02%) due to waffle-like AAO supporting the well-dispersed Ag nanoparticles. For real application, the AAO/Ag substrate is used for rapid determination of chloramphenicol (CAP) in honey with low detection limit (4.0 × 10−9 mol L−1) and good linearity from 1.0 × 10−5 to 1.0 × 10−8 mol L−1 based on the SERS peak at 1348 cm−1. The better accumulation in the short pore path of AAO improves the target molecule approaching into the vicinity of hot spots of Ag nanoparticles. The high selectivity for CAP is attributed to the strong interaction between -NO2 group in CAP and the composite substrate.

Schematic representation of the preparation of SERS substrate, AAO150/Ag10-5 composite nanoparticles, and antibiotic determination.

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Funding

This work is supported by the National Natural Science Foundation of China (no. 21475088, no. 21707091), International Joint Laboratory on Resource Chemistry (IJLRC), Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors.

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Authors and Affiliations

  1. Department of Chemistry, Key Laboratory of Resource Chemistry of Ministry of Education, 100 Guilin Road, Shanghai, 200234, People’s Republic of China

    Dongfang Xiao, Zhishun Jie, Zhiyuan Ma, Ye Ying, Xiaoyu Guo, Ying Wen & Haifeng Yang

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  1. Dongfang Xiao
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  2. Zhishun Jie
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  3. Zhiyuan Ma
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  4. Ye Ying
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  5. Xiaoyu Guo
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  6. Ying Wen
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  7. Haifeng Yang
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Correspondence to Ye Ying or Haifeng Yang.

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Electronic supplementary material

Fabrication of AAO; Surface morphologies; Optimization of the SERS substrate; The element mappings of the SEM on the AAO150/Ag10-5 substrate; FTIR spectra of substrates; SERS spectra of R6G with different concentrations on the flat aluminum foil with silver nanoparticles; The SERS intensity maps and the optical images of R6G (1.0×10-6 mol∙L-1) measured at a peak of 1511 cm-1 at different positions of the 25 x 25 μm2 from coffee ring SERS substrate with scanning step of 1 μm; The electric field intensity distribution of the nanoparticles is simulated on the substrate; The SERS spectra of honey samples with different CAP concentrations on the flat aluminum foil with silver nanoparticles; The limit of detection of the AAO150/Ag10-5 SERS substrate for the determination of chloramphenicol.

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Xiao, D., Jie, Z., Ma, Z. et al. Fabrication of homogeneous waffle-like silver composite substrate for Raman determination of trace chloramphenicol. Microchim Acta 187, 593 (2020). https://doi.org/10.1007/s00604-020-04567-2

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