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Primaries non-migraine headaches treatment: a review

  • THERAPEUTICAL SCENARIOS IN HEADACHES
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Abstract

In the “headache world,” great attention has always been paid to migraine patients, especially for the research and development of new therapies. For the other forms of primary headaches, especially those of Chapters 2 and 3 of the classification, there are however therapies that, even if not specific, can give significant results. Tension-type headache recognizes in NSAIDs the most effective drugs to treat acute attack, while prevention is based on the use of tricyclic antidepressants and muscle relaxants. For TACs, the discussion is more complex: first of all, there are two forms of primary headache that respond absolutely to indomethacin. For these, the main problem is how to manage the possible side effects arising from prolonged treatments and possibly what to use as an alternative. For cluster headaches and short-lasting unilateral neuralgiform headache attacks, we have drugs with good efficacy as regards medical therapy, such as verapamil or lamotrigine, but in recent years, neuromodulation techniques, both surgical and non-invasive, have also been affirming themselves, which represent a more possibility for forms of headache that are often very disabling and resistant to common analgesics.

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Authors and Affiliations

  1. Headache Center, Neurology and Stroke Unit S. Carlo Hospital, ASST Santi Paolo & Carlo, Via Pio II, N. 3, 20153, Milano, Italy

    Fabio Frediani

  2. National Neurological Institute Carlo Besta, Milano, Italy

    Gennaro Bussone

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  1. Fabio Frediani
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  2. Gennaro Bussone
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Correspondence to Fabio Frediani.

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Frediani, F., Bussone, G. Primaries non-migraine headaches treatment: a review. Neurol Sci 41 (Suppl 2), 385–394 (2020). https://doi.org/10.1007/s10072-020-04762-2

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