Corilagin Represses Epithelial to Mesenchymal Transition Process Through Modulating Wnt/β-Catenin Signaling Cascade
Abstract
:1. Introduction
2. Material and Methods
2.1. Reagents
2.2. Cell Lines and Culture Conditions
2.3. MTT Assay
2.4. Western Blot Analysis
2.5. Immunocytochemistry
2.6. Real-Time Cell Proliferation Analysis
2.7. Boyden Chamber Assay
2.8. Wound Healing Assay
2.9. Cell Transfection with β-Catenin siRNA
2.10. Statistical Analysis
3. Results
3.1. CLG Modulated the Expression of EMT Markers in Tumor Cells
3.2. CLG Effectively Attenuated Cellular Invasion and Migration
3.3. CLG Abrogated TGFβ-Induced EMT Cascade
3.4. CLG Suppressed TGFβ-Induced Metastatic Effects
3.5. CLG Down-Regulated TGFβ-Induced Activation of Wnt/β-Catenin Pathway
4. Discussions
Author Contributions
Funding
Conflicts of Interest
References
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Hwang, S.T.; Yang, M.H.; Kumar, A.P.; Sethi, G.; Ahn, K.S. Corilagin Represses Epithelial to Mesenchymal Transition Process Through Modulating Wnt/β-Catenin Signaling Cascade. Biomolecules 2020, 10, 1406. https://doi.org/10.3390/biom10101406
Hwang ST, Yang MH, Kumar AP, Sethi G, Ahn KS. Corilagin Represses Epithelial to Mesenchymal Transition Process Through Modulating Wnt/β-Catenin Signaling Cascade. Biomolecules. 2020; 10(10):1406. https://doi.org/10.3390/biom10101406
Chicago/Turabian StyleHwang, Sun Tae, Min Hee Yang, Alan Prem Kumar, Gautam Sethi, and Kwang Seok Ahn. 2020. "Corilagin Represses Epithelial to Mesenchymal Transition Process Through Modulating Wnt/β-Catenin Signaling Cascade" Biomolecules 10, no. 10: 1406. https://doi.org/10.3390/biom10101406