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Long non-coding RNAs: the tentacles of chromatin remodeler complexes

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Abstract

Chromatin remodeler complexes regulate gene transcription, DNA replication and DNA repair by changing both nucleosome position and post-translational modifications. The chromatin remodeler complexes are categorized into four families: the SWI/SNF, INO80/SWR1, ISWI and CHD family. In this review, we describe the subunits of these chromatin remodeler complexes, in particular, the recently identified members of the ISWI family and novelties of the CHD family. Long non-coding (lnc) RNAs regulate gene expression through different epigenetic mechanisms, including interaction with chromatin remodelers. For example, interaction of lncBRM with BRM inhibits the SWI/SNF complex associated with a differentiated phenotype and favors assembly of a stem cell-related SWI/SNF complex. Today, over 50 lncRNAs have been shown to affect chromatin remodeler complexes and we here discuss the mechanisms involved.

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Acknowledgements

This work was supported by grants from “Institut National de la Santé et de la Recherche Médicale” (Inserm), “Centre National de la Recherche Scientifique” (CNRS) and the “Cancéropôle Nord-Ouest” (Bourse Emergence 2019) and “Ligue Nationale contre le Cancer” (Comité Départemental CD59, CD80). The authors declare no conflict of interest. The funders had no role in the writing of the manuscript, or in the decision to publish this review.

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  1. Audrey Vincent and Isabelle Van Seuningen are last co-auteurs.

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  1. UMR9020-U1277 - CANTHER - Cancer Heterogeneity, Plasticity and Resistance to Therapies, Univ. Lille, CNRS, Inserm, CHU Lille, 59000, Lille, France

    Bernadette Neve, Nicolas Jonckheere, Audrey Vincent & Isabelle Van Seuningen

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  1. Bernadette Neve
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Neve, B., Jonckheere, N., Vincent, A. et al. Long non-coding RNAs: the tentacles of chromatin remodeler complexes. Cell. Mol. Life Sci. 78, 1139–1161 (2021). https://doi.org/10.1007/s00018-020-03646-0

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