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Effect of α2-Adrenergic Receptor Stimulation on the Isolated Rat Heart against the Background of If Blockade

  • BIOPHYSICS AND BIOCHEMISTRY
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Bulletin of Experimental Biology and Medicine Aims and scope

The study examined the effect of α2-adrenoreceptor (α2-AR) activation against the background of preliminary blockage of If on the performance of Langerndorff-isolated rat heart. Stimulation of α2-AR in isolated rat hearts against the background of ZD7288 in concentrations of 10—9 M and 3×10—5 M changed the negative dynamics of myocardial inotropy to positive (by 25 and 38%; p<0.05). Activation of α2-AR produced opposite effects on HR. If blockade abolished tachycardia caused by activation of α2-AR; HR deceleration in response to α2-AR agonist against the background of If blocker in a concentration 10—9 M was 41% (p<0.05). We observed negative dynamics of coronary flow (by 38%; p<0.05) in isolated adult rat hearts after application of α2-AR agonist against the background of If blockade (10—9 M).

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Authors and Affiliations

  1. Department of Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Republic of Tatarstan, Russia

    N. I. Ziyatdinova, A. M. Kuptsova, M. I. Sungatullina & T. L. Zefirov

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  1. N. I. Ziyatdinova
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  2. A. M. Kuptsova
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  3. M. I. Sungatullina
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  4. T. L. Zefirov
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Corresponding author

Correspondence to T. L. Zefirov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 5, pp. 564-567, May, 2020

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Ziyatdinova, N.I., Kuptsova, A.M., Sungatullina, M.I. et al. Effect of α2-Adrenergic Receptor Stimulation on the Isolated Rat Heart against the Background of If Blockade. Bull Exp Biol Med 169, 635–638 (2020). https://doi.org/10.1007/s10517-020-04943-1

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  • DOI: https://doi.org/10.1007/s10517-020-04943-1

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