Maternal or Paternal Diabetes and Its Crucial Role in Offspring Birth Weight and MODY Diagnosis
Abstract
:1. MODY-2 Scenario
Glucokinase GCK Mutation
2. MODY-1 Scenario
3. MODY-3 Scenario
HNF1A Mutations
4. MODY-5 Scenario
HNF1β Changes (Mutations/Deletions)
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
- Available online: https://www.omim.org/entry/606391 (accessed on 16 September 2020).
- Delvecchio, M.; Mozzillo, E.; Salzano, G.; Iafusco, D.; Frontino, G.; Patera, P.I.; Rabbone, I.; Cherubini, V.; Grasso, V.; Tinto, N.; et al. Monogenic diabetes accounts for 6.3% of cases referred to 15 Italian Pediatric Diabetes Centers during 2007 to 2012. J. Clin. Endocrinol. Metab. 2017, 102, 1826–1834. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Urakami, T. Maturity-onset diabetes of the young (MODY): Current perspectives on diagnosis and treatment. Diabetes Metab. Syndr. Obes. 2019, 12, 1047–1056. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Calcaterra, V.; Regalbuto, C.; Delle Cave, F.; Larizza, D.; Iafusco, D. GCK-MODY and obesity: Symptom overlap makes diagnosis difficult. Acta Diabetol. 2020, 57, 627–629. [Google Scholar] [CrossRef] [PubMed]
- Dickens, L.T.; Naylor, R.N. Clinical management of women with monogenic diabetes during Pregnancy. Curr. Diabetes Rep. 2018, 18, 12. [Google Scholar] [CrossRef] [PubMed]
- Rudland, V.L. Diagnosis and management of glucokinase monogenic diabetes in pregnancy: Current perspectives. Diabetes Metab. Syndr. Obes. 2019, 12, 1081–1089. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Monsonego, S.; Clark, H.; Karovitch, A.; O’Meara, P.; Shaw, T.; Malcolm, J. Management and Outcomes of Maturity-Onset Diabetes of the Young in Pregnancy. Can. J. Diabetes 2019, 43, 647–654. [Google Scholar] [CrossRef] [PubMed]
- Bitterman, O.; Tinto, N.; Franzese, A.; Iafusco, F.; Festa, C.; Mozzillo, E.; Napoli, A.; Iafusco, D. Glucokinase deficti and birthweight: Does maternal hypeglycemia always meet fetal needs? Acta Diabetol. 2018, 55, 1247–1250. [Google Scholar] [CrossRef] [PubMed]
- Bitterman, O.; Iafusco, D.; Torcia, F.; Tinto, N.; Napoli, A. A dizygotic twin pregnancy in a MODY-3 affected woman. Acta Diabetol. 2016, 53, 849–852. [Google Scholar] [CrossRef] [PubMed]
- Fowden, A.L. Insulin deficiency: Effects on fetal growth and development. J. Paediatr. Child Health 1993, 29, 6–11. [Google Scholar] [CrossRef] [PubMed]
- Ehrenberg, H.M.; Mercer, B.M.; Catalano, P.M. The influence of obesity and diabetes on the prevalence of macrosomia. Am. J. Obstet. Gynecol. 2004, 191, 964–968. [Google Scholar] [CrossRef] [PubMed]
- Scholl, T.O.; Sowers, M.; Chen, X.; Lenders, C. Maternal glucose concentration influences fetal growth, gestation, and pregnancy complications. Am. J. Epidemiol. 2001, 154, 514–520. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Verhave, J.C.; Bech, A.P.; Wetzels, J.F.; Nijenhuis, T. Hepatocyte Nuclear Factor 1β–Associated Kidney Disease: More than Renal Cysts and Diabetes. Am. Soc. Nephrol. 2016, 27, 345–353. [Google Scholar] [CrossRef] [PubMed] [Green Version]
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Share and Cite
Calcaterra, V.; Zanfardino, A.; Zuccotti, G.V.; Iafusco, D. Maternal or Paternal Diabetes and Its Crucial Role in Offspring Birth Weight and MODY Diagnosis. Metabolites 2020, 10, 387. https://doi.org/10.3390/metabo10100387
Calcaterra V, Zanfardino A, Zuccotti GV, Iafusco D. Maternal or Paternal Diabetes and Its Crucial Role in Offspring Birth Weight and MODY Diagnosis. Metabolites. 2020; 10(10):387. https://doi.org/10.3390/metabo10100387
Chicago/Turabian StyleCalcaterra, Valeria, Angela Zanfardino, Gian Vincenzo Zuccotti, and Dario Iafusco. 2020. "Maternal or Paternal Diabetes and Its Crucial Role in Offspring Birth Weight and MODY Diagnosis" Metabolites 10, no. 10: 387. https://doi.org/10.3390/metabo10100387