The emergence of antibiotic resistance is one of the most important public health concerns in the world. To solve this major problem, a series of antimicrobial compounds have been synthesized and tested against bacteria, yeast and fungi microorganisms. Thiazolidines and dithiolanes possess many biological activities against microbial strains. In this study, a facile free-solvent method for the synthesis of thiazolidine derivatives by one-pot reaction was developed and their biological activity was evaluated in comparison to 2-imino-1,3-dithiolanes. Microbial inhibition growth effects of the synthesized against microbial species compounds were characterized in terms of disk diffusion and minimum inhibitory concentration (MIC) methods, The MICs of the synthesized compounds were determined and the results showed that almost all synthesized compounds have antimicrobial potential. All thiazolidines are effective candidates for antimicrobial activity against C. albicans and A. niger species and all dithiolanes are strong antibiotics against P. aeruginosa.
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Acknowledgments
The authors would like to thank the University of Tabriz for financial support and Tabriz Applied Research Centre of Tabriz University of Medical Science for supporting this study with grant number 61703 with ethic committee confirmation number IR. TBZMED. VCR. REC.1397.412.
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Mehrabani, M.G., Safa, K.D., Rahimi, M. et al. Thiazolidine-2-Thione and 2-Imino-1,3-Dithiolane Derivatives: Synthesis and Evaluation of Antimicrobial Activity. Pharm Chem J 54, 588–595 (2020). https://doi.org/10.1007/s11094-020-02244-5
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DOI: https://doi.org/10.1007/s11094-020-02244-5