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Different Mechanisms of Cigarette Smoking-Induced Lung Cancer

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Abstract

The risk of cigarette smoking plays a pivotal role in increasing the incidence rates of lung cancer. This paper sheds new light on modeling the impact of cigarette smoking on lung cancer evolution, especially genetic instability and the number of gene mutations in the genome of stem cells. To handle this issue, we have set up stochastic multi-stage models to fit the data set of the probabilities of current and former smokers from the Nurses’ Health Study cohort of females (NHS) and the Health Professionals Follow up Study cohort of men (HPFS). Throughout this paper, we consider both mutation rates and clonal expansion rates as parameters in each compartment. For current and former smokers, three-driver mutations are most likely to take place in the progression of lung cancer under smoking risk. For current smokers, our findings reveal that two to sixteen gene mutations are required to obtain a cancerous cell among men and women in US. Moreover, two to six (eleven) cancer-mutations are available in the pathway to lung cancer among former smokers who have quit smoking for more (less) than ten years for both male and female patients. This highlights that cigarette smoking stimulates the number of driver mutations during lung tumorigenesis in both sexes. It is very crucial to examine the role of cigarette smoking in determining whether genomic instability is an early stage or late stage in the process of lung carcinogenesis.

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References

  • Armitage P, Doll R (1954) The age distribution of cancer and a multi-stage theory of carcinogenesis. Br J Cancer 8:1–12

    Article  Google Scholar 

  • Asatryan AD, Komarova NL (2016) Evolution of genetic instability in heterogeneous tumors. J Theor Biol 396:1–12

    Article  Google Scholar 

  • Bain C, Feskanich D, Speizer FE, Thun M, Hertzmark E, Rosner BA, Colditz GA (2004) Lung cancer rates in men and women with comparable histories of smoking. J Natl Cancer Inst 96:826–834

    Article  Google Scholar 

  • Bielas JH, Loeb LA (2005) Mutator phenotype in cancer: timing and perspectives. Environ Mol Mutagen 45:206–213

    Article  Google Scholar 

  • Brody JP (2011) Age-specific incidence data indicate four mutations are required for human testicular cancers. PloS ONE 6:e25978

    Article  Google Scholar 

  • Brown CC, Chu KC (1983) Implications of the multistage theory of carcinogenesis applied to occupational arsenic exposure. J Natl Cancer Instit 70:455–463

    Google Scholar 

  • Cassidy A, Field JK (2007) Environmental and genetic risk factors of lung cancer, outcome prediction in cancer. Elsevier, New York, pp 67–100

    Book  Google Scholar 

  • Chen LS, Kaphingst KA, Tseng TS, Zhao S (2016) How are lung cancer risk perceptions and cigarette smoking related?-testing an accuracy hypothesis. Translational cancer research 5:S964–S971

    Article  Google Scholar 

  • Cruz CSD, Tanoue LT, Matthay RA (2011) Lung cancer: epidemiology, etiology, and prevention. Clin Chest Med 32:605–644

    Article  Google Scholar 

  • Day NE, Brown CC (1980) Multistage models and primary prevention of cancer. J Natl Cancer Instit 64:977–989

    Google Scholar 

  • Gaffney M, Altshuler B (1988) Examination of the role of cigarette smoke in lung carcinogenesis using multistage models1. J Natl Cancer Instit 80:925–931

    Article  Google Scholar 

  • Hahn WC, Weinberg RA (2002) Modelling the molecular circuitry of cancer. Nat Rev Cancer 2:331–341

    Article  Google Scholar 

  • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57–70

    Article  Google Scholar 

  • Harris TE (2002) The theory of branching processes. Applied mathematics series. Prentice-Hall, Englewood CLiffs

    Google Scholar 

  • Heidenreich WF, Luebeck EG, Moolgavkar SH (1997) Some properties of the hazard function of the two-mutation clonal expansion model. Risk Anal 17:391–399

    Article  Google Scholar 

  • Henschke CI, Miettinen OS (2004) Women’s susceptibility to tobacco carcinogens. Lung Cancer 43:1–5

    Article  Google Scholar 

  • Jain M, Burch JD, Howe GR, Risch HA, Miller AB (1990) Dietary factors and risk of lung cancer: results from a case–control study, Toronto, 1981–1985. Int J Cancer 45:287–293

    Article  Google Scholar 

  • Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ (2008) Cancer statistics. CA Cancer J Clin 58:71–96

    Article  Google Scholar 

  • Khuder SA (2001) Effect of cigarette smoking on major histological types of lung cancer: a meta-analysis. Lung Cancer 31:139–148

    Article  Google Scholar 

  • Kvåle G, Bjelke E, Gart JJ (1983) Dietary habits and lung cancer risk. Int J Cancer 31:397–405

    Article  Google Scholar 

  • Leffondre K, Abrahamowicz M, Siemiatycki J, Rachet B (2002) Modeling smoking history: a comparison of different approaches. American journal of epidemiology 156:813–823

    Article  Google Scholar 

  • Lengauer C, Kinzler KW, Vogelstein B (1998) Genetic instabilities in human cancers. Nature 396:643–649

    Article  Google Scholar 

  • Li L, Tian T, Zhang X (2017) The impact of radiation on the development of lung cancer. J Theor Biol 428:147–152

    Article  Google Scholar 

  • Li L, Tian T, Zhang X (2018) Mutation mechanisms of human breast cancer. J Comput Biol 25:396–404

    Article  Google Scholar 

  • Li L, Tian T, Zhang X (2019) Stochastic modelling of multistage carcinogenesis and progression of human lung cancer. J Theor Biol 479:81–89

    Article  Google Scholar 

  • Loeb LA (1991) Mutator phenotype may be required for multistage carcinogenesis. Cancer Res 51:3075–3079

    Google Scholar 

  • Loeb LA, Loeb KR, Anderson JP (2003) Multiple mutations and cancer. Proc Natl Acad Sci 100:776–781

    Article  Google Scholar 

  • Malvezzi M, Carioli G, Bertuccio P et al (2016) European cancer mortality predictions for the year 2016 with focus on leukaemias. Ann Oncol 27:725–731

    Article  Google Scholar 

  • Marx J (2002) Debate surges over the origins of genomic defects in cancer. Science 297:544–546

    Article  Google Scholar 

  • Meza R, Jeon J, Moolgavkar SH, Luebeck EG (2008) Age-specific incidence of cancer: Phases, transitions, and biological implications. Proc Natl Acad Sci 105:16284–16289

    Article  Google Scholar 

  • Meza R, Hazelton WD, Colditz GA, Moolgavkar SH (2008) Analysis of lung cancer incidence in the nurses’ health and the health professionals’ follow-up studies using a multistage carcinogenesis model. Cancer Causes Control 19:317–328

    Article  Google Scholar 

  • Moolgavkar SH, Luebeck G (1990) Two-event model for carcinogenesis: biological, mathematical, and statistical considerations. Risk Anal 10:323–341

    Article  Google Scholar 

  • Moolgavkar SH, Day NE, Stevens RG (1980) Two-stage model for carcinogenesis: epidemiology of breast cancer in females. J Natl Cancer Instit 65:559–569

    Google Scholar 

  • Moolgavkar SH, Holford TR, Levy DT et al (2012) Impact of reduced tobacco smoking on lung cancer mortality in the United States during 1975–2000. J Natl Cancer Instit 104:541–548

    Article  Google Scholar 

  • Nagah A, Amer A, Zhang X (2019) The effect of cigarette smoking on lung cancer evolution. Math Biosci Eng 16:7771–7788

    Article  Google Scholar 

  • Nordling CO (1953) A new theory on the cancer-inducing mechanism. Br J Cancer 7:68–72

    Article  Google Scholar 

  • Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74–108

    Article  Google Scholar 

  • Ray G, Henson DE, Schwartz AM (2010) Cigarette smoking as a cause of cancers other than lung cancer: an exploratory study using the Surveillance. Epidemiol End Results Program Chest 138:491–499

    Google Scholar 

  • Schöllnberger H, Beerenwinkel N, Hoogenveen R, Vineis P (2010) Cell selection as driving force in lung and colon carcinogenesis. Cancer Res 70:6797–6803

    Article  Google Scholar 

  • Shih IM, Zhou W, Goodman SN, Lengauer C, Kinzler KW, Vogelstein B (2001) Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis. Cancer Res 61:818–822

    Google Scholar 

  • Siegel RL, Miller KD, Jemal A (2015) Cancer statistics. CA Cancer J Clin 65:5–29

    Article  Google Scholar 

  • Siegel RL, Miller KD, Jemal A (2018) Cancer statistics. CA Cancer J Clin 68:7–30

    Article  Google Scholar 

  • Stratton MR, Campbell PJ, Futreal PA (2009) The cancer genome. Nature 458:719–724

    Article  Google Scholar 

  • Thun MJ, Henley SJ, Burns D, Jemal A, Shanks TG, Calle EE (2006) Lung cancer death rates in lifelong nonsmokers. J Natl Cancer Instit 98:691–699

    Article  Google Scholar 

  • Tomasetti C, Marchionni L, Nowak MA, Parmigiani G, Vogelstein B (2015) Only three driver gene mutations are required for the development of lung and colorectal cancers. Proc Natl Acad Sci 112:118–123

    Article  Google Scholar 

  • Vogelstein B, Kinzler KW (1993) The multistep nature of cancer. Trends Genetics 9:138–141

    Article  Google Scholar 

  • Vogelstein B, Kinzler KW (2004) Cancer genes and the pathways they control. Nat Med 10:789–799

    Article  Google Scholar 

  • Wynder EL, Hoffmann D (1994) Smoking and lung cancer: scientific challenges and opportunities. Cancer Res 54:5284–5294

    Google Scholar 

  • Yang P, Cerhan JR, Vierkant RA et al (2002) Adenocarcinoma of the lung is strongly associated with cigarette smoking: further evidence from a prospective study of women. Am J Epidemiol 156:1114–1122

    Article  Google Scholar 

  • Zang EA, Wynder EL (1996) Differences in lung cancer risk between men and women: examination of the evidence. J Natl Cancer Instit 88:183–192

    Article  Google Scholar 

  • Zhang X, Simon R (2005) Estimating the number of rate limiting genomic changes for human breast cancer. Breast Cancer Res Treat 91:121–124

    Article  Google Scholar 

  • Zhang X, Fang Y, Zhao Y, Zheng W (2014) Mathematical modeling the pathway of human breast cancer. Math Biosci 253:25–29

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. School of Mathematics and Statistics, Central China Normal University, Wuhan, 430079, P. R. China

    Ahmed Nagah & Asmaa Amer

  2. Faculty of Science, Mathematics Department, Zagazig University, Zagazig, Egypt

    Ahmed Nagah

  3. Faculty of Science, Mathematics Department, Menoufia University, Menoufia, Egypt

    Asmaa Amer

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  1. Ahmed Nagah
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  2. Asmaa Amer
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Correspondence to Ahmed Nagah.

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Nagah, A., Amer, A. Different Mechanisms of Cigarette Smoking-Induced Lung Cancer. Acta Biotheor 69, 37–52 (2021). https://doi.org/10.1007/s10441-020-09394-9

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