Electrophilic groups that undergo sulfur-exchange chemistry with protein nucleophiles can serve as the functional basis of chemical proteomic probes. A new addition to this class, sulfuramidimidoyl fluoride (SAF), which can be included in an array of covalent small molecule probes, exhibits a unique reactivity profile with proteins.
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Speltz, T.E., Moellering, R.E. Protein targeting with SAF(er) electrophiles. Nat. Chem. 12, 885–887 (2020). https://doi.org/10.1038/s41557-020-00553-6
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DOI: https://doi.org/10.1038/s41557-020-00553-6
