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Dielectric-Backed Aperture Resonators for X-band Depth-Limited in Vivo EPR Nail Dosimetry

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Abstract

A new resonant geometry for X-band in vivo electron paramagnetic resonance (EPR) nail dosimetry has been developed, fabricated, and tested. The dielectric-backed aperture resonator (DAR) was specifically designed for depth-limited surface spectroscopy. The DAR improves EPR sensitivity of surface samples with sub-millimeter thicknesses by at least a factor of 20 compared to other aperture resonator designs. The increase in EPR sensitivity was achieved using a non-resonant dielectric slab which is placed on the aperture inside the cavity. The dielectric slab provides an increased microwave magnetic field, while minimizing the problematic resonance conditions of the aperture. It has been shown that the DAR provides sufficient sensitivity to make biologically-relevant measurements both in vitro and in vivo. This work demonstrates that in vivo tests with an equivalent dosimetry sensitivity of approximately 1.4 Gy are feasible. Plausible ways to further increase the sensitivity are discussed, such as, the introduction and simulations of a DAR based on a semi-spherical TE011 geometry.

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Acknowledgements

This work is supported by Centers for Medical Countermeasures Against Radiation (CMCR) in the National Institute of Allergy and Infectious Diseases (NIAID) in the [Grant Number U19AI091173]; and the National Biomedical Electron Paramagnetic Resonance Center in the National Institute of Biomedical Imaging and Bioengineering (NIBIB) [Grant Number P41EB001980] of the National Institute of Health.

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Authors and Affiliations

  1. Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA

    Oleg Grinberg, Dmitriy Tipikin, Vladimir Krymov & Harold M. Swartz

  2. Department of Radiation Oncology, University of Florida, Gainesville, FL, 32610, USA

    Steven G. Swarts

  3. Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, 53211, USA

    Jason W. Sidabras

  4. EPR Research Group, Max Planck for Chemical Energy Conversion, 45468, Mülheim an der Ruhr, Germany

    Jason W. Sidabras

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  1. Oleg Grinberg
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  2. Jason W. Sidabras
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  4. Vladimir Krymov
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  5. Steven G. Swarts
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  6. Harold M. Swartz
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Correspondence to Oleg Grinberg.

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Grinberg, O., Sidabras, J.W., Tipikin, D. et al. Dielectric-Backed Aperture Resonators for X-band Depth-Limited in Vivo EPR Nail Dosimetry. Appl Magn Reson 51, 1093–1101 (2020). https://doi.org/10.1007/s00723-020-01259-1

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  • DOI: https://doi.org/10.1007/s00723-020-01259-1

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